Xiaoyan Hu, Xiaoling Hu, Yangdan Zhu, Huijia Hu, Zhuoping Wang
{"title":"血清半乳甘露聚糖抗原对阻塞性肺疾病(哮喘和慢性阻塞性肺疾病)患者侵袭性曲霉病诊断的敏感性","authors":"Xiaoyan Hu, Xiaoling Hu, Yangdan Zhu, Huijia Hu, Zhuoping Wang","doi":"10.5114/ada.2024.145208","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Adverse clinical outcomes often result from the concomitant presence of invasive pulmonary aspergillosis (IPA) in patients with obstructive pulmonary diseases (asthma and chronic obstructive pulmonary diseases (COPD)).</p><p><strong>Aim: </strong>This work was developed to assess the risk factors (RFs) for patients with concurrent IPA and the diagnostic sensitivity of existing detection methods.</p><p><strong>Material and methods: </strong>This was a case control study on patients with acute exacerbation of obstructive pulmonary diseases (OPD) hospitalized from January 2022 to December 2023; patients were categorized into an IPA group (<i>n</i> = 39) and a non-IPA group (<i>n</i> = 37) based on test results. Information about smoking history, diabetes history, usage of broad-spectrum antibiotics (BSAs) and corticosteroids, and serum albumin levels were collected. After univariate analysis, a multivariate logistic regression (MLR) analysis was performed. Additionally, the diagnostic sensitivity and specificity of GM antigen, IgG, and IgM detection were compared.</p><p><strong>Results: </strong>Prolonged use of BSAs (≥ 2 weeks) and corticosteroids (≥ 3 weeks), along with low albumin levels emerged as independent RFs for concurrent IPA. The sensitivity of GM antigen detection (64.1%) was the highest among the three methods, with specificity slightly lower than IgG detection (75.68%, 81.08%), yet still not reaching the ideal level.</p><p><strong>Conclusions: </strong>Risk assessment for asthma and COPD patients with concurrent IPA should encompass an evaluation of prolonged antibiotic and steroid use, along with a comprehensive consideration of nutritional and immune status. Current IPA detection methods should be evaluated in conjunction with clinical conditions to enhance diagnostic accuracy.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"183-189"},"PeriodicalIF":1.4000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163962/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sensitivity of serum galactomannan antigen in the diagnosis of invasive aspergillosis in patients with obstructive pulmonary diseases (asthma and chronic obstructive pulmonary diseases).\",\"authors\":\"Xiaoyan Hu, Xiaoling Hu, Yangdan Zhu, Huijia Hu, Zhuoping Wang\",\"doi\":\"10.5114/ada.2024.145208\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Adverse clinical outcomes often result from the concomitant presence of invasive pulmonary aspergillosis (IPA) in patients with obstructive pulmonary diseases (asthma and chronic obstructive pulmonary diseases (COPD)).</p><p><strong>Aim: </strong>This work was developed to assess the risk factors (RFs) for patients with concurrent IPA and the diagnostic sensitivity of existing detection methods.</p><p><strong>Material and methods: </strong>This was a case control study on patients with acute exacerbation of obstructive pulmonary diseases (OPD) hospitalized from January 2022 to December 2023; patients were categorized into an IPA group (<i>n</i> = 39) and a non-IPA group (<i>n</i> = 37) based on test results. Information about smoking history, diabetes history, usage of broad-spectrum antibiotics (BSAs) and corticosteroids, and serum albumin levels were collected. After univariate analysis, a multivariate logistic regression (MLR) analysis was performed. Additionally, the diagnostic sensitivity and specificity of GM antigen, IgG, and IgM detection were compared.</p><p><strong>Results: </strong>Prolonged use of BSAs (≥ 2 weeks) and corticosteroids (≥ 3 weeks), along with low albumin levels emerged as independent RFs for concurrent IPA. The sensitivity of GM antigen detection (64.1%) was the highest among the three methods, with specificity slightly lower than IgG detection (75.68%, 81.08%), yet still not reaching the ideal level.</p><p><strong>Conclusions: </strong>Risk assessment for asthma and COPD patients with concurrent IPA should encompass an evaluation of prolonged antibiotic and steroid use, along with a comprehensive consideration of nutritional and immune status. Current IPA detection methods should be evaluated in conjunction with clinical conditions to enhance diagnostic accuracy.</p>\",\"PeriodicalId\":54595,\"journal\":{\"name\":\"Postepy Dermatologii I Alergologii\",\"volume\":\"42 2\",\"pages\":\"183-189\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-11-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163962/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Postepy Dermatologii I Alergologii\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5114/ada.2024.145208\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Postepy Dermatologii I Alergologii","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5114/ada.2024.145208","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}
Sensitivity of serum galactomannan antigen in the diagnosis of invasive aspergillosis in patients with obstructive pulmonary diseases (asthma and chronic obstructive pulmonary diseases).
Introduction: Adverse clinical outcomes often result from the concomitant presence of invasive pulmonary aspergillosis (IPA) in patients with obstructive pulmonary diseases (asthma and chronic obstructive pulmonary diseases (COPD)).
Aim: This work was developed to assess the risk factors (RFs) for patients with concurrent IPA and the diagnostic sensitivity of existing detection methods.
Material and methods: This was a case control study on patients with acute exacerbation of obstructive pulmonary diseases (OPD) hospitalized from January 2022 to December 2023; patients were categorized into an IPA group (n = 39) and a non-IPA group (n = 37) based on test results. Information about smoking history, diabetes history, usage of broad-spectrum antibiotics (BSAs) and corticosteroids, and serum albumin levels were collected. After univariate analysis, a multivariate logistic regression (MLR) analysis was performed. Additionally, the diagnostic sensitivity and specificity of GM antigen, IgG, and IgM detection were compared.
Results: Prolonged use of BSAs (≥ 2 weeks) and corticosteroids (≥ 3 weeks), along with low albumin levels emerged as independent RFs for concurrent IPA. The sensitivity of GM antigen detection (64.1%) was the highest among the three methods, with specificity slightly lower than IgG detection (75.68%, 81.08%), yet still not reaching the ideal level.
Conclusions: Risk assessment for asthma and COPD patients with concurrent IPA should encompass an evaluation of prolonged antibiotic and steroid use, along with a comprehensive consideration of nutritional and immune status. Current IPA detection methods should be evaluated in conjunction with clinical conditions to enhance diagnostic accuracy.