Correlation Between the J-MACS, HeartMate3, and J-HeartMate Risk Scores and Their Prognostic Impact in Japanese Patients With Heart Failure - A Retrospective Study.

Background: In addition to the J-HeartMate Risk Score (J-HMRS) and HeartMate 3 Risk Score (HM3RS), the J-MACS Risk Score (J-MACS-RS) was developed to predict death after left ventricular assist device (LVAD) implantation in Japanese patients with heart failure (HF). However, the correlation between these scores, the characteristics of high-risk patients as per these scores, and the mortality stratification of these scores in HF patients regardless of LVAD implantation are still not fully understood.

Methods and results: Hospitalized patients with HF who underwent echocardiography and right heart catheterization were included (n=269). Patients at low or medium risk per the J-HMRS or HM3RS and at high risk per the J-MACS-RS (LM_J-HMH_J-MACS and LM_HM3H_J-MACS, respectively) were compared with those at low or medium risk per both scores (LM_J-HMLM_J-MACSand LM_HM3LM_J-MACS, respectively). The J-MACS-RS was well associated with the J-HMRS (r=0.66) and HM3RS (r=0.65). Patients with LM_J-HMH_J-MACS were older and showed a higher prevalence of ischemic etiology and history of cardiac surgery than those with LM_J-HMLM_J-MACS. LM_J-HMH_J-MACS and LM_HM3H_J-MACSshowed higher serum creatinine levels and central venous pressure-to-pulmonary artery wedge pressure ratios than LM_J-HMLM_J-MACSand LM_HM3LM_J-MACS, respectively. All scores stratified the 3-year mortality in patients with HF.

Conclusions: The J-MACS-RS correlated well with the J-HMRS and HM3RS. These scores may predict 3-year mortality, even in Japanese HF patients, regardless of LVAD implantation.