Muhana F Ilyas, Revi G H Novika, Winastari Y Triniputri, I M E W Pradipta, Ni W P S Ksamawati, Nurul J Wahidah, Hartono Hartono, Lanjar Sumarno
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Statistical analysis utilized Chi-square or Fisher exact tests, Mann-Whitney or independent t-tests, and multiple linear regression.</p><p><strong>Results: </strong>No significant demographic differences were found, except in hospitalization status. Clinically, pregnant female had a higher prevalence of symptoms such as cough (<i>p</i> = 0.002), fatigue (<i>p</i> = 0.025), and shortness of breath (<i>p</i> = 0.035), with no differences in other symptoms or length of stay. Laboratory findings indicated significant differences in White Cell Count (WCC), Absolute Lymphocyte Count (ALC), High Fluorescence Lymphocyte Count (HFLC), lymphocyte percentage, neutrophil percentage, Neutrophil Lymphocyte Ratio (NLR), Red Cell Count (RCC), Hemoglobin (Hb), Hematocrit (Hct), Platelet Count (PC), Prothrombin Time (PT), International Normalized Ratio (INR), D-Dimer, and Sodium (<i>p</i> values < 0.05). Multivariate analysis identified WCC, lymphocyte percentage, HFLC, neutrophil percentage, PT, INR, D-Dimer, Creatinine, and Potassium as significant predictors of length of stay (R²adj = 0.874, F = 17.979, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Pregnant female with COVID-19 exhibited distinct laboratory profiles compared to non-pregnant female. These findings highlight the need for tailored management strategies for COVID-19 in pregnant patients and provide a foundation for further research.</p>","PeriodicalId":44816,"journal":{"name":"Iranian Journal of Nursing and Midwifery Research","volume":"30 3","pages":"322-331"},"PeriodicalIF":1.2000,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164763/pdf/","citationCount":"0","resultStr":"{\"title\":\"Differences in Clinical and Laboratory Features of Pregnant and Non-Pregnant Female with Hospitalized COVID-19.\",\"authors\":\"Muhana F Ilyas, Revi G H Novika, Winastari Y Triniputri, I M E W Pradipta, Ni W P S Ksamawati, Nurul J Wahidah, Hartono Hartono, Lanjar Sumarno\",\"doi\":\"10.4103/ijnmr.ijnmr_86_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The impact of COVID-19 on vulnerable populations, including pregnant female, is critical due to higher risks and potential complications. 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引用次数: 0
摘要
背景：COVID-19对包括孕妇在内的弱势人群的影响至关重要，因为风险更高，可能出现并发症。本研究旨在比较妊娠和非妊娠女性COVID-19的临床和实验室特征。材料和方法：本回顾性队列研究纳入了2020年3月至2022年5月在印度尼西亚萨贝拉斯市场大学（UNS）医院住院的245例COVID-19患者。其中怀孕72人，未怀孕173人。从医疗记录中收集人口统计、临床表现和实验室结果的数据。统计分析采用卡方检验或Fisher精确检验、Mann-Whitney检验或独立t检验和多元线性回归。结果：除住院情况外，两组间无统计学差异。临床上，孕妇咳嗽（p = 0.002）、疲劳（p = 0.025）、呼吸短促（p = 0.035）等症状的发生率较高，其他症状和住院时间无差异。实验室结果显示，白细胞计数（WCC）、绝对淋巴细胞计数（ALC）、高荧光淋巴细胞计数（HFLC）、淋巴细胞百分比、中性粒细胞百分比、中性粒细胞淋巴细胞比率（NLR）、红细胞计数（RCC）、血红蛋白（Hb）、红细胞压积（Hct）、血小板计数（PC）、凝血酶原时间（PT）、国际标准化比率（INR）、d -二聚体和钠含量均有显著差异（p值< 0.05）。多因素分析发现WCC、淋巴细胞百分比、HFLC、中性粒细胞百分比、PT、INR、d -二聚体、肌酐和钾是住院时间的显著预测因子（R²adj = 0.874, F = 17.979, p < 0.001）。结论：与未怀孕女性相比，怀孕女性COVID-19表现出不同的实验室特征。这些发现突出了针对妊娠患者COVID-19量身定制管理策略的必要性，并为进一步研究奠定了基础。
Differences in Clinical and Laboratory Features of Pregnant and Non-Pregnant Female with Hospitalized COVID-19.
Background: The impact of COVID-19 on vulnerable populations, including pregnant female, is critical due to higher risks and potential complications. This study aims to compare the clinical and laboratory features of COVID-19 between pregnant and non-pregnant female.
Materials and methods: This retrospective cohort study included 245 COVID-19 patients admitted to Universitas Sabellas Maret (UNS) Hospital, Indonesia, from March 2020 to May 2022. Among them, 72 were pregnant, and 173 were non-pregnant. Data on demographics, clinical presentations, and laboratory findings were collected from medical records. Statistical analysis utilized Chi-square or Fisher exact tests, Mann-Whitney or independent t-tests, and multiple linear regression.
Results: No significant demographic differences were found, except in hospitalization status. Clinically, pregnant female had a higher prevalence of symptoms such as cough (p = 0.002), fatigue (p = 0.025), and shortness of breath (p = 0.035), with no differences in other symptoms or length of stay. Laboratory findings indicated significant differences in White Cell Count (WCC), Absolute Lymphocyte Count (ALC), High Fluorescence Lymphocyte Count (HFLC), lymphocyte percentage, neutrophil percentage, Neutrophil Lymphocyte Ratio (NLR), Red Cell Count (RCC), Hemoglobin (Hb), Hematocrit (Hct), Platelet Count (PC), Prothrombin Time (PT), International Normalized Ratio (INR), D-Dimer, and Sodium (p values < 0.05). Multivariate analysis identified WCC, lymphocyte percentage, HFLC, neutrophil percentage, PT, INR, D-Dimer, Creatinine, and Potassium as significant predictors of length of stay (R²adj = 0.874, F = 17.979, p < 0.001).
Conclusions: Pregnant female with COVID-19 exhibited distinct laboratory profiles compared to non-pregnant female. These findings highlight the need for tailored management strategies for COVID-19 in pregnant patients and provide a foundation for further research.
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