南苏拉威西的结直肠癌:非遗传危险因素的病例对照研究。

IF 3.1 Q2 ONCOLOGY
Oncology Reviews Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI:10.3389/or.2025.1589655
Upik A Miskad, Matthew Martianus Henry, Carissa Ikka Pardamean, Arif Budiarto, Akram Irwan, James W Baurley, Irawan Yusuf, Bens Pardamean
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引用次数: 0

摘要

背景:本研究通过病例对照研究分析了南苏拉威西人群中导致结直肠癌(CRC)发病率的非遗传危险因素。方法:患者89例,对照组84例,年龄19 ~ 86岁,男99例,女74例,不同民族。单因素分析采用卡方检验、Fisher精确检验、t检验和Mann-Whitney U检验。通过logit模型L1正则化选择重要的非遗传危险因素,并根据年龄、性别和种族进行调整。分析的危险因素为患者的体重、身高、体质指数(BMI)、排便地点、运动习惯、吸烟习惯、婚姻状况、职业、受教育程度和到最近的卫生中心的距离。使用logit模型估计的优势比来分析所选危险因素的显著性。结果:logit模型的显著危险因素为吸烟习惯、文化程度、婚姻状况、距离最近的保健中心的距离和体重。结直肠癌患者受教育程度较低(OR = 1.819, 95% CI 1.354-2.443),居住在偏远地区(OR = 1.44, 95% CI 1.17-1.772),体重下降(OR = 1.03, 95% CI 1.013-1.048)的可能性较大。对照组更有可能是非吸烟者(OR = 0.325, 95% CI 0.149-0.707)和未婚者(OR = 0.161, 95% CI 0.036-0.716)。结论:该研究确定了其他非遗传风险因素,包括教育水平、与最近的卫生中心的距离、体重、吸烟习惯和婚姻状况,有助于南苏拉威西人口中结直肠癌的发病率。该研究强调了考虑这些风险因素对于进一步有针对性地预防结直肠癌的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Colorectal cancer in south sulawesi: a case-control study for nongenetic risk factors.

Background: This study analyzed the nongenetic risk factors that contributed to colorectal cancer (CRC) incidence in the South Sulawesi population through a case-control study.

Methods: The sample consisted of 89 cases and 84 controls, aged between 19-86, with 99 males and 74 females from different ethnic groups. Univariate analysis was carried out using chi-square, Fisher's exact test, t -test, and Mann-Whitney U test. Significant nongenetic risk factors were selected through the logit model L1 regularization, adjusted for age, gender, and ethnicity. The analyzed risk factors were the patient's weight, height, body mass index (BMI), defecation location, exercise habit, smoking habit, marital status, occupation, education level, and distance to the nearest health center. The estimated odds ratio from the logit model was used to analyze the significance of the selected risk factors.

Results: The significant risk factors from the logit model were smoking habit, education level, marital status, distance to the nearest health center, and weight. CRC cases were more likely to have lower education (OR = 1.819, 95% CI 1.354-2.443), residing in remote areas (OR = 1.44, 95% CI 1.17-1.772), experiencing decreasing weight (OR = 1.03, 95% CI 1.013-1.048). Controls were more likely to be non-smokers (OR = 0.325, 95% CI 0.149-0.707) and unmarried (OR = 0.161, 95% CI 0.036-0.716).

Conclusion: The study determined that other nongenetic risk factors, including education level, distance to the nearest health center, weight, smoking habit, and marital status, contributed to the CRC incidence within the South Sulawesi population. The study emphasized the importance in accounting for these risk factors for further, targeted CRC preventions.

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来源期刊
Oncology Reviews
Oncology Reviews ONCOLOGY-
CiteScore
6.30
自引率
0.00%
发文量
9
审稿时长
9 weeks
期刊介绍: Oncology Reviews is a quarterly peer-reviewed, international journal that publishes authoritative state-of-the-art reviews on preclinical and clinical aspects of oncology. The journal will provide up-to-date information on the latest achievements in different fields of oncology for both practising clinicians and basic researchers. Oncology Reviews aims at being international in scope and readership, as reflected also by its Editorial Board, gathering the world leading experts in both pre-clinical research and everyday clinical practice. The journal is open for publication of supplements, monothematic issues and for publishing abstracts of scientific meetings; conditions can be obtained from the Editor-in-Chief or the publisher.
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