欧洲蟾蜍的异配子转变改变了关键脊椎动物性别决定基因的性别连锁,并与巨大的性染色体效应有关。

IF 5.3 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Christophe Dufresnes, Pierre-André Crochet, Beata Rozenblut-Kościsty, Spartak N Litvinchuk, Nicolas Rodrigues, Nicolas Perrin, Daniel L Jeffries
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引用次数: 0

摘要

描述两栖动物性染色体的多样性和不稳定性是理解驱动性染色体翻转的原因和评估性连锁基因在生殖隔离和物种形成中的作用的关键。本研究表明,以前报道的杂交蟾蜍Bufo Bufo (ZW)和B. spinosus (XY)之间的异配子转变是非同源的,可能涉及脊椎动物性别决定级联的关键基因(SOX9, DMRT1, AMH),其特征是ZW比XY片段短得多。将这些信息与已发表的杂交区数据相结合,表明两种性染色体都比常染色体更能抵抗种间渗入。这些观察结果证实,性染色体翻转优先涉及宿主保守的性别决定基因的染色体,暗示异交是性染色体分化的关键因素,并且与大的性染色体效应一致,这是一种物种形成的经验法则,而非同态性染色体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Heterogametic Transition in European Bufo Toads Switches the Sex Linkage of Key Vertebrate Sex Determination Genes and Associates with a Large Sex Chromosome Effect.

Characterizing the diversity and lability of the amphibian sex chromosomes holds key to understand what drives sex chromosome turnovers and assess the role of sex-linked genes in reproductive isolation and speciation. Here, we show that the heterogametic transition previously reported between the hybridizing toads Bufo bufo (ZW) and Bufo spinosus (XY) is nonhomologous, potentially implicates key genes of the vertebrate sex determination cascade (SOX9, DMRT1, and AMH), and is characterized by a much shorter ZW than XY segment. Integrating this information with published hybrid zone data suggests that both sex chromosomes resist interspecific introgression more than autosomes. These observations substantiate that sex chromosome turnovers preferentially involve chromosomes that host conserved sex-determining genes, imply heterochiasmy as a key factor of sex chromosome differentiation, and are consistent with a large sex chromosome effect, an empirical rule of speciation that is not expected with homomorphic sex chromosomes.

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来源期刊
Molecular biology and evolution
Molecular biology and evolution 生物-进化生物学
CiteScore
19.70
自引率
3.70%
发文量
257
审稿时长
1 months
期刊介绍: Molecular Biology and Evolution Journal Overview: Publishes research at the interface of molecular (including genomics) and evolutionary biology Considers manuscripts containing patterns, processes, and predictions at all levels of organization: population, taxonomic, functional, and phenotypic Interested in fundamental discoveries, new and improved methods, resources, technologies, and theories advancing evolutionary research Publishes balanced reviews of recent developments in genome evolution and forward-looking perspectives suggesting future directions in molecular evolution applications.
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