{"title":"铂源纳米治疗慢性伤口愈合的创新进展及临床应用。","authors":"Jie Yang, Qingyu Han, Liping Li, Ruiping Zhang","doi":"10.1016/j.mtbio.2025.101929","DOIUrl":null,"url":null,"abstract":"<p><p>Chronic wounds are a major public health concern worldwide because their complex pathophysiological processes and multifactorial etiology substantially complicate therapeutic interventions, highlighting the urgency of developing novel intervention approaches. Platinum-derived (Pt-derived) nanomaterials, owing to their distinctive biophysical characteristics and catalytic functionalities, have demonstrated promising therapeutic capabilities in chronic wound management. Nevertheless, critical gaps remain in understanding their clinical translation and effectiveness. In this context, the present review systematically investigated the structure-bioactivity relationships of Pt-derived nanocomposites and hybrid systems while evaluating their biomedical multivalency and combinatory approaches in therapeutic applications. In addition, the limitations currently impeding the practical implementation of Pt-derived nanotherapeutics and prospects for future advancements in material optimisation and biological integration strategies are addressed.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"101929"},"PeriodicalIF":8.7000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163165/pdf/","citationCount":"0","resultStr":"{\"title\":\"Innovative progress and clinical utilization of platinum-derived nanotherapeutics for chronic wound healing.\",\"authors\":\"Jie Yang, Qingyu Han, Liping Li, Ruiping Zhang\",\"doi\":\"10.1016/j.mtbio.2025.101929\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Chronic wounds are a major public health concern worldwide because their complex pathophysiological processes and multifactorial etiology substantially complicate therapeutic interventions, highlighting the urgency of developing novel intervention approaches. Platinum-derived (Pt-derived) nanomaterials, owing to their distinctive biophysical characteristics and catalytic functionalities, have demonstrated promising therapeutic capabilities in chronic wound management. Nevertheless, critical gaps remain in understanding their clinical translation and effectiveness. In this context, the present review systematically investigated the structure-bioactivity relationships of Pt-derived nanocomposites and hybrid systems while evaluating their biomedical multivalency and combinatory approaches in therapeutic applications. In addition, the limitations currently impeding the practical implementation of Pt-derived nanotherapeutics and prospects for future advancements in material optimisation and biological integration strategies are addressed.</p>\",\"PeriodicalId\":18310,\"journal\":{\"name\":\"Materials Today Bio\",\"volume\":\"32 \",\"pages\":\"101929\"},\"PeriodicalIF\":8.7000,\"publicationDate\":\"2025-05-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163165/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials Today Bio\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1016/j.mtbio.2025.101929\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Today Bio","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.mtbio.2025.101929","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Innovative progress and clinical utilization of platinum-derived nanotherapeutics for chronic wound healing.
Chronic wounds are a major public health concern worldwide because their complex pathophysiological processes and multifactorial etiology substantially complicate therapeutic interventions, highlighting the urgency of developing novel intervention approaches. Platinum-derived (Pt-derived) nanomaterials, owing to their distinctive biophysical characteristics and catalytic functionalities, have demonstrated promising therapeutic capabilities in chronic wound management. Nevertheless, critical gaps remain in understanding their clinical translation and effectiveness. In this context, the present review systematically investigated the structure-bioactivity relationships of Pt-derived nanocomposites and hybrid systems while evaluating their biomedical multivalency and combinatory approaches in therapeutic applications. In addition, the limitations currently impeding the practical implementation of Pt-derived nanotherapeutics and prospects for future advancements in material optimisation and biological integration strategies are addressed.
期刊介绍：
Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).
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