红藻赤藻素A-C的化学结构及防污活性研究。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-06-13 DOI:10.1016/j.fitote.2025.106683

Ryosuke Fukada, Keisuke Nishikawa, Misaki Nagasaka, Masayuki Kirihara, Shinobu Takizawa, Yoshiki Morimoto, Kazumi Nimura, Norio Kikuchi, Yukimasa Yamagishi, Takahiro Ishii, Takashi Kamada

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引用次数: 0

摘要

我们的实验旨在寻找能够抑制贻贝体内足丝形成的海洋天然产物。从日本千叶县胜浦县吉雄的海洋红藻Laurencia sp.中分离到3个新的labdane型溴化二萜，分别为yoshioapplyins A-C（1-3）。通过红外光谱、核磁共振、高分辨率质谱和化学合成等方法确定了它们的结构。化合物1 ~ 3与从同一地点采集的金银花中分离得到的金银花素-20(7)/金银花素-20醛(8)存在对映异构体。此外，化合物1 ~ 3在浓度低至0.16 μmol/cm2时，对加洛省贻贝（Mytilus galloprovincialis）具有显著的防污活性。我们相信这些新的溴化二萜可以作为天然的防污药物。

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Chemical structure and antifouling activity of yoshioaplysins A-C isolated from red alga genus Laurencia.

Our experiments aim to find marine natural products that inhibit byssus thread formation in mussels. Three new labdane-type brominated diterpenes, yoshioaplysins A-C (1-3), were isolated from the marine red alga Laurencia sp. collected from Yoshio (Katsuura, Chiba Prefecture, Japan). Their structures were established using IR, NMR, high-resolution MS, and chemical synthesis. An enantiodivergent phenomenon was observed between compounds 1-3 and aplysin-20 (7) / aplysin-20 aldehyde (8) previously isolated from L. venusta collected from the same location. Moreover, compounds 1-3 showed a remarkable antifouling activity against the mussel Mytilus galloprovincialis at concentrations as low as 0.16 μmol/cm². We believe that these new brominated diterpenes can be used as natural antifouling drugs.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.