进展性核上性麻痹与其他神经退行性疾病的弥散张量成像研究进展

IF 2.3 4区 医学 Q3 CLINICAL NEUROLOGY
Alexandros Giannakis, Spiridon Konitsiotis, Georgia Xiromerisiou
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引用次数: 0

摘要

进行性核上性麻痹(PSP)是一种复杂的神经退行性疾病,经常被误诊,很大程度上是因为它与其他神经退行性疾病如帕金森病和多系统萎缩有重叠的临床特征。准确和早期诊断仍然是一个重大的临床挑战。在这种情况下,扩散张量成像(DTI),一种专门的磁共振成像技术,测量神经组织中水分子的定向运动,已经成为一种有前途的生物标志物。本文综述了DTI在PSP与其他神经退行性疾病鉴别中的应用。多项研究报道了DTI参数的显著变化,特别是分数各向异性和平均弥漫性,在关键的大脑区域,包括小脑上脚、丘脑、皮质脊髓束、胼胝体前部和前额皮质。虽然经典的放射学征象,如蜂鸟和米老鼠征象,对经典理查森综合征(PSP- rs)仍然具有高度的特异性,优于本回顾研究中强调的任何结果,但在与其他PSP亚型相关的区域,如额叶皮层,DTI的诊断准确率很高,这一点可以在未来的研究中得到更多的探索。然而,样本量小、异质性研究设计以及主要关注PSP-RS亚型等局限性限制了更广泛的推广。大规模、多中心的研究是必要的,以验证这些发现,跨越不同的PSP表现,并建立DTI作为一个强大的诊断工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diffusion Tensor Imaging in Progressive Supranuclear Palsy Versus Other Neurodegenerative Diseases: A Review

Progressive supranuclear palsy (PSP) is a complex neurodegenerative disorder that is frequently misdiagnosed, largely due to its overlapping clinical features with other neurodegenerative diseases, such as Parkinson's disease and multiple system atrophy. Accurate and early diagnosis remains a significant clinical challenge. In this context, diffusion tensor imaging (DTI), a specialized magnetic resonance imaging technique that measures the directional movement of water molecules in neural tissue, has emerged as a promising biomarker. This narrative review synthesizes current research on the utility of DTI in differentiating PSP from other neurodegenerative diseases. Multiple studies have reported significant alterations in DTI parameters—particularly fractional anisotropy and mean diffusivity—in key brain regions, including the superior cerebellar peduncle, thalamus, corticospinal tract, anterior parts of the corpus callosum, and prefrontal cortex. While classical radiological signs such as the hummingbird and Mickey Mouse signs remain highly specific for the classic Richardson syndrome (PSP-RS), superior to any results highlighted by studies of this review, in areas associated with other PSP subtypes, such as the frontal cortex, DTI has scored high rates of diagnostic accuracy, a point that could be more explored in future research efforts. Nonetheless, limitations including small sample sizes, heterogeneous study designs, and a predominant focus on the PSP-RS subtype restrict broader generalizability. Large-scale, multicenter studies are necessary to validate these findings across the diverse spectrum of PSP presentations and to establish DTI as a robust diagnostic tool.

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来源期刊
Journal of Neuroimaging
Journal of Neuroimaging 医学-核医学
CiteScore
4.70
自引率
0.00%
发文量
117
审稿时长
6-12 weeks
期刊介绍: Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!
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