年轻女性胃肠道肿瘤患者生育能力保存的管理：一个病例系列和系统的文献综述

IF 2.5 4区医学 Q3 ONCOLOGY

Current Problems in Cancer Pub Date : 2025-06-17 DOI:10.1016/j.currproblcancer.2025.101221

Gabriella Gentile , Mariavita Ciccarone

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引用次数: 0

摘要

由于化疗、放疗和手术干预的促性腺毒性作用，年轻女性的胃肠道（GI）癌症对生育能力构成了重大挑战。虽然有保留生育能力的选择，但咨询仍然没有得到充分利用，限制了患者的生育选择。本系统综述和病例系列研究了胃肠道肿瘤治疗对女性生育能力、可用保存技术、妊娠结局和性功能障碍的影响。尽管在保持生育能力方面取得了进步，但实施仍然不够理想，强调需要采用多学科方法来改善咨询和生殖结果。提高认识和促进早期干预可以加强生育能力保存工作，改善年轻女性癌症幸存者的生活质量。

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Management of fertility preservation in young female patients with gastrointestinal cancer: A case series and systematic literature review

Gastrointestinal (GI) cancers in young women pose significant challenges to fertility due to the gonadotoxic effects of chemotherapy, radiotherapy, and surgical interventions. While fertility preservation options exist, counseling remains underutilized, limiting patients' reproductive choices. This systematic review and case series examine the impact of GI cancer treatments on female fertility, available preservation techniques, pregnancy outcomes and sexual dysfunction. Despite advancements in fertility preservation, implementation remains suboptimal, underscoring the need for a multidisciplinary approach to improve counseling and reproductive outcomes. Raising awareness and promoting early intervention can enhance fertility preservation efforts and improve the quality of life for young female cancer survivors.

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来源期刊

Current Problems in Cancer 医学-肿瘤学

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

15 days

期刊介绍： Current Problems in Cancer seeks to promote and disseminate innovative, transformative, and impactful data on patient-oriented cancer research and clinical care. Specifically, the journal''s scope is focused on reporting the results of well-designed cancer studies that influence/alter practice or identify new directions in clinical cancer research. These studies can include novel therapeutic approaches, new strategies for early diagnosis, cancer clinical trials, and supportive care, among others. Papers that focus solely on laboratory-based or basic science research are discouraged. The journal''s format also allows, on occasion, for a multi-faceted overview of a single topic via a curated selection of review articles, while also offering articles that present dynamic material that influences the oncology field.