西爪哇的甲状腺癌：它并不都是乳头状的和漂亮的

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-06-17 DOI:10.1016/j.canep.2025.102869

Kiki Akhmad Rizki , Rantapina Kurniasari , Monty Priosadewo , Maman Abdurrahman , Raden Yohana Azhar , Dodi Lumbal Gaol , Rupita Sari Endangena Sitanggang , Zuldi Erdiansyah , Prapanca Nugraha , Arrayyan Muhammad , Etis Primastari

{"title":"西爪哇的甲状腺癌：它并不都是乳头状的和漂亮的","authors":"Kiki Akhmad Rizki , Rantapina Kurniasari , Monty Priosadewo , Maman Abdurrahman , Raden Yohana Azhar , Dodi Lumbal Gaol , Rupita Sari Endangena Sitanggang , Zuldi Erdiansyah , Prapanca Nugraha , Arrayyan Muhammad , Etis Primastari","doi":"10.1016/j.canep.2025.102869","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Thyroid cancer is the most common endocrine malignancy in children and adults. The rising incidence of thyroid cancer, which remains poorly understood, raises the need to evaluate whether this increase will lead to higher mortality and more aggressive disease. This study aimed to describe the characteristics of thyroid cancer at the largest hospital in West Java and to examine the relationships between these characteristics.</div></div><div><h3>Methods</h3><div>This was an observational study. The subjects were patients with thyroid tumors in the oncology surgery division of a tertiary hospital in West Java, Indonesia, from January 2017 to December 2022. A total of 3414 subjects were included in the study. The characteristics of the thyroid tumors were extracted from medical records.</div></div><div><h3>Results</h3><div>The results showed that the mean age of the participants was 47 years, thyroid tumors were more common in women (82.9 %), and tumor location was frequently found on the right side (38.6 %) and over 90 % of cases showed no lymph node metastasis. Univariate analysis confirmed significant associations between histology and patient sex, tumor location, size, and nodal status (all p < 0.05), with very few subcentimeter tumors and higher metastatic rates in papillary (30.3 %) and medullary (37.5 %) carcinomas.</div></div><div><h3>Conclusion</h3><div>Thyroid cancer, particularly papillary thyroid carcinoma, was prevalent in the study population, with significant associations between histopathology, sex, tumor size, and lymph node metastasis. These findings highlight the important of using risk-based FNA and selective surgical referral to exclude low-risk microcarcinomas. Adherence to these strategies will mitigate overdiagnosis and unnecessary surgery.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"97 ","pages":"Article 102869"},"PeriodicalIF":2.4000,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Thyroid cancer in West Java: It’s not all papillary and pretty\",\"authors\":\"Kiki Akhmad Rizki , Rantapina Kurniasari , Monty Priosadewo , Maman Abdurrahman , Raden Yohana Azhar , Dodi Lumbal Gaol , Rupita Sari Endangena Sitanggang , Zuldi Erdiansyah , Prapanca Nugraha , Arrayyan Muhammad , Etis Primastari\",\"doi\":\"10.1016/j.canep.2025.102869\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Thyroid cancer is the most common endocrine malignancy in children and adults. The rising incidence of thyroid cancer, which remains poorly understood, raises the need to evaluate whether this increase will lead to higher mortality and more aggressive disease. This study aimed to describe the characteristics of thyroid cancer at the largest hospital in West Java and to examine the relationships between these characteristics.</div></div><div><h3>Methods</h3><div>This was an observational study. The subjects were patients with thyroid tumors in the oncology surgery division of a tertiary hospital in West Java, Indonesia, from January 2017 to December 2022. A total of 3414 subjects were included in the study. The characteristics of the thyroid tumors were extracted from medical records.</div></div><div><h3>Results</h3><div>The results showed that the mean age of the participants was 47 years, thyroid tumors were more common in women (82.9 %), and tumor location was frequently found on the right side (38.6 %) and over 90 % of cases showed no lymph node metastasis. Univariate analysis confirmed significant associations between histology and patient sex, tumor location, size, and nodal status (all p < 0.05), with very few subcentimeter tumors and higher metastatic rates in papillary (30.3 %) and medullary (37.5 %) carcinomas.</div></div><div><h3>Conclusion</h3><div>Thyroid cancer, particularly papillary thyroid carcinoma, was prevalent in the study population, with significant associations between histopathology, sex, tumor size, and lymph node metastasis. These findings highlight the important of using risk-based FNA and selective surgical referral to exclude low-risk microcarcinomas. Adherence to these strategies will mitigate overdiagnosis and unnecessary surgery.</div></div>\",\"PeriodicalId\":56322,\"journal\":{\"name\":\"Cancer Epidemiology\",\"volume\":\"97 \",\"pages\":\"Article 102869\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-06-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Epidemiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1877782125001298\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Epidemiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1877782125001298","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景：甲状腺癌是儿童和成人最常见的内分泌恶性肿瘤。甲状腺癌的发病率不断上升，这一点仍然知之甚少，因此需要评估这种增加是否会导致更高的死亡率和更具侵袭性的疾病。本研究旨在描述在西爪哇最大的医院甲状腺癌的特点，并检查这些特点之间的关系。方法观察性研究。研究对象为2017年1月至2022年12月在印度尼西亚西爪哇省某三级医院肿瘤外科治疗的甲状腺肿瘤患者。本研究共纳入3414名受试者。从病历中提取甲状腺肿瘤的特征。结果研究对象的平均年龄为47岁，甲状腺肿瘤以女性多见（82.9 %），肿瘤多发于右侧（38.6 %），90% %以上的病例无淋巴结转移。单因素分析证实组织学与患者性别、肿瘤位置、大小和淋巴结状态之间存在显著关联（p均为 <； 0.05），亚厘米肿瘤很少，乳头状癌（30.3% %）和髓样癌（37.5% %）的转移率较高。结论甲状腺癌，尤其是乳头状甲状腺癌，在研究人群中普遍存在，与组织病理学、性别、肿瘤大小和淋巴结转移有显著相关性。这些发现强调了使用基于风险的FNA和选择性手术转诊来排除低风险微癌的重要性。坚持这些策略将减少过度诊断和不必要的手术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Thyroid cancer in West Java: It’s not all papillary and pretty

Background

Thyroid cancer is the most common endocrine malignancy in children and adults. The rising incidence of thyroid cancer, which remains poorly understood, raises the need to evaluate whether this increase will lead to higher mortality and more aggressive disease. This study aimed to describe the characteristics of thyroid cancer at the largest hospital in West Java and to examine the relationships between these characteristics.

Methods

This was an observational study. The subjects were patients with thyroid tumors in the oncology surgery division of a tertiary hospital in West Java, Indonesia, from January 2017 to December 2022. A total of 3414 subjects were included in the study. The characteristics of the thyroid tumors were extracted from medical records.

Results

The results showed that the mean age of the participants was 47 years, thyroid tumors were more common in women (82.9 %), and tumor location was frequently found on the right side (38.6 %) and over 90 % of cases showed no lymph node metastasis. Univariate analysis confirmed significant associations between histology and patient sex, tumor location, size, and nodal status (all p < 0.05), with very few subcentimeter tumors and higher metastatic rates in papillary (30.3 %) and medullary (37.5 %) carcinomas.

Conclusion

Thyroid cancer, particularly papillary thyroid carcinoma, was prevalent in the study population, with significant associations between histopathology, sex, tumor size, and lymph node metastasis. These findings highlight the important of using risk-based FNA and selective surgical referral to exclude low-risk microcarcinomas. Adherence to these strategies will mitigate overdiagnosis and unnecessary surgery.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.