基于天然呋喃香豆素和上转化稀土金属颗粒的光敏剂对Lewis肺癌和B16黑色素瘤小鼠的抗肿瘤疗效和药代动力学研究

IF 2.2 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Vasilisa I. Shlyapkina , Mikhail N. Zharkov , Denis E. Yakobson , Nikolay A. Pyataev , Ekaterina S. Prikhozhdenko , Alexey A. Burtasov , Olga I. Balakireva , Irina A. Gololobova , Anna A. Gadeeva , Vladislav S. Bobrov , Oleg A. Kulikov
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引用次数: 0

摘要

本文研究了一种含有天然呋喃香豆素的光敏剂和具有紫外发光的上转化微粒nayf4: 20% Yb, 0.25% Tm在体内肿瘤生长模型上的光疗潜力。本研究包括评估光敏剂在恶性肿瘤模型小鼠(Lewis肺癌和B16黑色素瘤)中的抗肿瘤功效、药代动力学和生物物理特性。研究的结果是,开发了一种液体形式的实验光敏剂,该光敏剂是一种从Heracleum sosnowskyi植物中提取的呋喃香豆素乳液,其中含有nayf4: 20% Yb, 0.25% Tm (EmFHS-UCPs)的微粒。EmFHS-UCPs光敏剂的有机和无机成分的药代动力学研究结果证实了在实验光疗中使用肿瘤内给药途径。在可移植的Lewis肺癌小鼠中,瘤内注射EmFHS-UCPs,然后进行激光照射(λ-980 nm),结果显示抑制肿瘤生长,肿瘤结节减少,并提高荷瘤动物的存活率。B16黑色素瘤小鼠无抗肿瘤作用。一项使用实验动物组织的离体研究证实了影响紫外线(365 nm)和红外(980 nm)辐射抗肿瘤光疗成功的生物物理原因。研究表明,含有nayf4: 20% Yb, 0.25% Tm微粒子的乳状呋喃香豆素的抗肿瘤效果直接取决于光敏剂的最佳给药途径和肿瘤组织的光学性质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Study of antitumor efficacy and pharmacokinetics of a photosensitizer based on natural furanocoumarins and upconversion rare earth metal particles in mice with Lewis lung carcinoma and B16 melanoma

Study of antitumor efficacy and pharmacokinetics of a photosensitizer based on natural furanocoumarins and upconversion rare earth metal particles in mice with Lewis lung carcinoma and B16 melanoma
In this work, the phototherapeutic potential of a photosensitizer containing natural furanocoumarins and upconversion microparticles NaYF4:20 %Yb,0.25 %Tm, possessing UV luminescence, was investigated on an in vivo tumor growth model.
The study included an assessment of the antitumor efficacy, pharmacokinetics and biophysical properties of the photosensitizer in mice with malignant neoplasm models (Lewis lung carcinoma and B16 melanoma).
As a result of the study, a liquid form of the experimental photosensitizer was developed, which is an emulsion of furanocoumarins from the Heracleum sosnowskyi plant, which contained microparticles of NaYF4:20 %Yb,0.25 %Tm (EmFHS-UCPs).
The results of the study of the pharmacokinetics of organic and inorganic components of the EmFHS-UCPs photosensitizer substantiate the use of the intratumoral route of administration in experimental phototherapy.
In mice with transplantable Lewis lung carcinoma, intratumoral injection of EmFHS-UCPs followed by laser irradiation (λ-980 nm) was shown to result in inhibition of tumor growth, tumor nodule reduction, and increased survival of tumor-bearing animals.
No antitumor effect was detected in mice with B16 melanoma.
An ex vivo study using tissues from experimental animals substantiated the biophysical reasons affecting the success of antitumor phototherapy using UV (365 nm) and IR (980 nm) radiation.
The study showed that the degree of antitumor efficacy of emulsion furanocoumarins containing NaYF4:20 %Yb,0.25 %Tm microparticles directly depends on the optimal route of photosensitizer administration and optical properties of tumor tissues.
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来源期刊
Biochemical and biophysical research communications
Biochemical and biophysical research communications 生物-生化与分子生物学
CiteScore
6.10
自引率
0.00%
发文量
1400
审稿时长
14 days
期刊介绍: Biochemical and Biophysical Research Communications is the premier international journal devoted to the very rapid dissemination of timely and significant experimental results in diverse fields of biological research. The development of the "Breakthroughs and Views" section brings the minireview format to the journal, and issues often contain collections of special interest manuscripts. BBRC is published weekly (52 issues/year).Research Areas now include: Biochemistry; biophysics; cell biology; developmental biology; immunology ; molecular biology; neurobiology; plant biology and proteomics
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