氮杂七烯与供体-受体环丙烷的正式高阶[8 + 3]环加成

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-06-16 DOI:10.1002/ejoc.202500331

Junjie Xi, Wang Liu, Guochun Li, Xiaoyan Zhang, Yujiao Xiang, Yonghai Hui, Xin Zhou, Weiliang Chen, Yungui Peng

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引用次数: 0

摘要

环庚[b]吡啶衍生物因其独特的生物活性而受到广泛关注。在此，我们描述了一种有效的方法，通过Yb(OTf)3催化氮杂七富尔烯与供体环丙烷的形式高阶[8+3]环加成来获得各种环庚[b]吡啶衍生物。该方法具有广泛的底物亲和性，产物收率高，选择性好。

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Formal Higher‐Order [8 + 3] Cycloaddition of Azaheptafulvenes with Donor‐Acceptor Cyclopropanes

Cyclohepta[b]pyridine derivatives have attracted significant attention owing to their unique bioactivities. Herein, we describe an efficient method to access various cyclohepta[b]pyridine derivatives through formal higher‐order [8+3] cycloaddition of azaheptafulvenes with donor‐acceptor cyclopropanes catalyzed by Yb(OTf)3. This method exhibited broad substrate accommodation and gave the corresponding products in high yields and selectivity.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.