用于H2S生物标志物检测的耐湿Pt/CrVN2燃料电池传感器。

IF 8.2 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors Pub Date : 2025-06-16 DOI:10.1021/acssensors.5c01358

Zhaorui Zhang,Chonghui Zhu,Yu Liang,Jinkui Chu,Yuxia Shan,Minghui Yang

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引用次数: 0

摘要

实时、远程监测人体生物标志物对于个性化医疗诊断至关重要。硫化氢（H2S）是一种关键的内源性气体，是口腔疾病等疾病的重要生物标志物。然而，在高湿环境中准确检测ppb级H2S仍然是一个挑战。在此，我们开发了一种pt负载的CrVN2燃料电池型H2S传感器，具有高抗湿性、超低检测限（50 ppb）、快速响应（4 s）和卓越的选择性。CrVN2稳定的电子结构确保在较宽的相对湿度范围内（9%-79%）具有一致的响应。此外，设计并验证了一种结合Pt/CrVN2传感器的无线检测系统，用于呼吸诊断，展示了其在智能医疗中的实际应用。这项研究强调了Pt/CrVN2传感器作为实时、灵敏的生物标志物检测平台的潜力，有助于推进下一代医学诊断。

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Humidity-Resistant Pt/CrVN2 Fuel Cell Sensor for H2S Biomarker Detection.

Real-time, remote monitoring of human biomarkers is essential for personalized medical diagnostics. Hydrogen sulfide (H2S), a key endogenous gas, serves as a crucial biomarker for conditions such as oral diseases. However, accurately detecting ppb-level H2S in high-humidity environments remains a challenge. Herein, we develop a Pt-loaded CrVN2 fuel cell-type H2S sensor that exhibits high humidity resistance, ultralow detection limits (50 ppb), rapid response (4 s), and exceptional selectivity. The stable electronic structure of CrVN2 ensures a consistent response across a wide relative humidity range (9%-79%). Furthermore, a wireless detection system incorporating the Pt/CrVN2 sensor was designed and validated for breath diagnosis, demonstrating its practical application in smart healthcare. This study highlights the potential of Pt/CrVN2 sensor as a promising platform for real-time, sensitive biomarker detection, contributing to the advancement of next-generation medical diagnostics.

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来源期刊

ACS Sensors Chemical Engineering-Bioengineering

CiteScore

14.50

自引率

3.40%

发文量

372

期刊介绍： ACS Sensors is a peer-reviewed research journal that focuses on the dissemination of new and original knowledge in the field of sensor science, particularly those that selectively sense chemical or biological species or processes. The journal covers a broad range of topics, including but not limited to biosensors, chemical sensors, gas sensors, intracellular sensors, single molecule sensors, cell chips, and microfluidic devices. It aims to publish articles that address conceptual advances in sensing technology applicable to various types of analytes or application papers that report on the use of existing sensing concepts in new ways or for new analytes.