超声诱导血脑屏障打开在神经病学和免疫学中的应用。

IF 12.1 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2025-06-16 DOI:10.1002/smll.202502699

Anan Jiang,Zijie Wang,Dan Song,Xinyu Zhang,Mengtong Guan,Xinhe Li,Jindong Tan,Yi He,Wang Han,Xiaoqian Ding,Xiaoyu Han,Faqi Li,Dingqun Bai

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引用次数: 0

摘要

血脑屏障（BBB）作为一个严格的生物过滤器，位于循环系统和大脑组织之间，通过防止有害的神经毒性物质进入中枢神经系统（CNS）来保护大脑。然而，血脑屏障也限制了大多数治疗药物的进入，导致目前只有少数药物可用于神经系统疾病的临床治疗。因此，迫切需要发现一种安全有效的技术来暂时破坏血脑屏障，以达到直接给药的目的。超声诱导血脑屏障打开结合药物给药的治疗方法具有无创性、精准靶向、深入组织渗透等优点。它克服了被血脑屏障阻断的传统疗法的局限性，在治疗神经系统疾病方面显示出巨大的潜力。本文综述了血脑屏障的物理特性和运输机制，然后介绍了超声介导的血脑屏障打开的机制。综述了超声打开血脑屏障后的神经和免疫调节，重点介绍了其特点及其在免疫治疗中的临床应用。这些广泛的见解旨在为超声介导的血脑屏障开放的临床应用提供有希望的策略，以实现靶向和个性化的药物递送。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Application of Ultrasound-Induced Blood-Brain Barrier Opening in Neurology and Immunology.

The blood-brain barrier (BBB) acts as a stringent biological filter situated between the circulatory system and the brain's tissue, shielding the brain by preventing the entry of detrimental neurotoxic substances into the central nervous system (CNS). Nevertheless, the BBB also restricts the entry of most therapeutic drugs, resulting in only a few medications currently available for the clinical treatment of neurological diseases. Consequently, it is imperative to discover a secure and potent technique to temporarily disrupt the BBB for the purpose of directed medication administration. The therapeutic approach of ultrasound-induced BBB opening combined with drug delivery offers advantages such as non-invasiveness, precise targeting, and deep tissue penetration. It overcomes the limitations of traditional therapies blocked by the BBB and shows significant potential for treating neurological disorders. This review includes an overview of the physical characteristics and transport mechanisms of the BBB, followed by an introduction to the mechanisms of ultrasound-mediated BBB opening. Additionally, it summarizes the neural and immune regulation following BBB opening by ultrasound, with a focus on its features and clinical applications in immunotherapy. These extensive insights aim to provide promising strategies for the clinical application of ultrasound-mediated BBB opening for targeted and personalized drug delivery.

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.