控制侵袭性念珠菌病的二价脂质体疫苗的临床前评价。

IF 6.9 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2025-06-13 DOI:10.1038/s41541-025-01183-0

Augusto Costa-Barbosa, Maria Inês Pacheco, Andreia C Gomes, Tony Collins, Manuel Vilanova, Célia Pais, Alexandra Correia, Paula Sampaio

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引用次数: 0

摘要

尽管进行了抗真菌治疗，但在危重病人和免疫功能低下的病人中，白色念珠菌引起全身感染，死亡率为20-50%。目前的治疗方法面临局限性，包括毒性和耐药性，强调需要预防性疫苗。本研究提出了一种新的二价脂质体疫苗，可递送白色念珠菌Cht3和Sap2抗原。在侵袭性念珠菌病小鼠模型中，接种疫苗可诱导保护性Th1/Th17免疫、平衡Th1/Th2比例、抗原特异性抗体，并提高巨噬细胞活性，提高生存率。

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Pre-clinical evaluation of a divalent liposomal vaccine to control invasive candidiasis.

Candida albicans causes systemic infections with 20-50% mortality in critically ill and immunocompromised patients, despite antifungal treatment. Current therapies face limitations, including toxicity and resistance, underscoring the need for prophylactic vaccines. This study presents a novel divalent liposomal vaccine, delivering C. albicans Cht3 and Sap2 antigens. Vaccination induced protective Th1/Th17 immunity, a balanced Th1/Th2 ratio, antigen-specific antibodies, and boosted macrophage activity, improving survival in a mouse model of invasive candidiasis.

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.