Shana J Kim, Jasleen Arneja, Rebecca A G Christensen, Geoff M Anderson, Jennifer D Brooks
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Trends in contralateral breast cancer and contralateral prophylactic mastectomy from 2009 to 2016.
This study characterizes trends in contralateral breast cancer (CBC) and contralateral prophylactic mastectomy (CPM) in Ontario, Canada, by breast cancer risk level. Overall, there has been a decline in CBC rates and the concomitant rise in CPM rates after unilateral breast cancer diagnosis, largely driven by high-risk individuals. Considerations for breast cancer risk level are recommended in evaluations of CBC and CPM trends.
期刊介绍:
npj Breast Cancer publishes original research articles, reviews, brief correspondence, meeting reports, editorial summaries and hypothesis generating observations which could be unexplained or preliminary findings from experiments, novel ideas, or the framing of new questions that need to be solved. Featured topics of the journal include imaging, immunotherapy, molecular classification of disease, mechanism-based therapies largely targeting signal transduction pathways, carcinogenesis including hereditary susceptibility and molecular epidemiology, survivorship issues including long-term toxicities of treatment and secondary neoplasm occurrence, the biophysics of cancer, mechanisms of metastasis and their perturbation, and studies of the tumor microenvironment.