免疫球蛋白E在病毒免疫中的作用？

IF 4.9 3区医学 Q2 IMMUNOLOGY

Immunology Pub Date : 2025-06-13 DOI:10.1111/imm.70007

Amanda Izeli Portilho, Valéria Oliveira Silva, Luis Fernando de Macedo Brigido, Elizabeth De Gaspari

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引用次数: 0

摘要

免疫球蛋白E在过敏症和寄生虫病中被广泛研究。然而，抗原特异性IgE已被确定为对某些病毒的体液反应的一部分，包括呼吸道合胞病毒（RSV）、人鼻病毒（HRV）、流感、乙型肝炎病毒（HBV）、人类免疫缺陷病毒（HIV）、单纯疱疹病毒（HSV）、登革热病毒（DENV）和SARS-CoV-2。在这篇简短的文章中，我们回顾了IgE的功能和结构的关键方面，并总结了该抗体在病毒特异性免疫反应中的发现。迄今为止，面对病毒的IgE效应机制几乎没有通过功能分析来探索。我们推测可能的功能，如中和，细胞毒性和病毒性疾病的免疫病理学，并提供有关空白的见解，以填补未来的研究。

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Should We Advance Our Understanding of Immunoglobulin E in Viral Immunity?

Immunoglobulin E has been extensively studied in allergies and parasitic diseases. However, antigen-specific IgE has been identified as part of the humoral response to some viruses, including Respiratory syncytial virus (RSV), Human rhinovirus (HRV), Influenza, Hepatitis B virus (HBV), Human immunodeficiency virus (HIV), Herpes simplex virus (HSV), Dengue virus (DENV) and SARS-CoV-2. In this brief article, we have reviewed key aspects of IgE function and structure, and summarised the findings about this antibody in virus-specific immune response. To date, IgE effector mechanisms in the face of viruses have been almost unexplored through functional assays. We speculate on possible functionalities, such as neutralisation, cytotoxicity and immunopathology of viral diseases, and provide insights about gaps to fill in future research.

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来源期刊

Immunology 医学-免疫学

CiteScore

11.90

自引率

1.60%

发文量

175

审稿时长

4-8 weeks

期刊介绍： Immunology is one of the longest-established immunology journals and is recognised as one of the leading journals in its field. We have global representation in authors, editors and reviewers. Immunology publishes papers describing original findings in all areas of cellular and molecular immunology. High-quality original articles describing mechanistic insights into fundamental aspects of the immune system are welcome. Topics of interest to the journal include: immune cell development, cancer immunology, systems immunology/omics and informatics, inflammation, immunometabolism, immunology of infection, microbiota and immunity, mucosal immunology, and neuroimmunology. The journal also publishes commissioned review articles on subjects of topical interest to immunologists, and commissions in-depth review series: themed sets of review articles which take a 360° view of select topics at the heart of immunological research.