Chang Cao, Jing Yuan, Elizabeth R Gilbert, Mark A Cline, Fan Lam, King C Li, Ryan N Dilger
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引用次数: 0
摘要
目的：本研究旨在定量评估2型糖尿病患者循环白细胞介素浓度数据。方法：我们使用PubMed、Web of Science和Cochrane Library进行系统综述。原始研究报告了至少一组2型糖尿病患者（肥胖2型糖尿病[OBD]、超重2型糖尿病[OWD]或瘦弱2型糖尿病[LD]）和健康体重对照（HWCs）的循环白细胞介素浓度数据。数据来自43项纳入的研究，由独立研究者单独纳入2646例2型糖尿病患者和6605例HWCs患者。我们使用随机效应模型在综合Meta-Analysis Version 2软件中汇集数据。效应量（Effect size, ESs）计算为各组间白细胞介素浓度的标准化平均差异，然后转化为Hedge’s g统计量。结果：我们的研究结果显示，与HWCs相比，2型糖尿病患者的循环浓度更高，包括IL-4、IL-6、IL-17和IL-18。当按BMI亚组分层时，与HWCs相比，所有2型糖尿病患者的IL-6浓度均升高，其中OBD患者的ES最高，其次是OWD和LD。与总体结果相似，与HWCs相比，不同BMI亚组的2型糖尿病患者的IL-4 （OWD）、IL-17 （LD）和IL-18 （OBD，但不包括OWD）的白介素浓度较高。结论：荟萃分析结果显示，2型糖尿病患者中IL-4、IL-6、IL-17和IL-18的循环浓度较高，加强了2型糖尿病伴有全身炎症反应的临床证据。
Increased Circulating Interleukin Concentrations in Type 2 Diabetes: A Systematic Review and Meta-Analysis.
Objectives: This work aimed to quantitatively evaluate circulating interleukin concentration data available for patients with Type 2 diabetes.
Methods: We performed a systematic review using PubMed, Web of Science, and the Cochrane Library. Original studies reporting data on circulating interleukin concentrations in at least one group of patients with Type 2 diabetes (obese Type 2 diabetes [OBD], overweight Type 2 diabetes [OWD], or lean Type 2 diabetes [LD]) and healthy weight controls (HWCs) were included. Data were extracted from 43 included studies uniquely encompassing 2646 patients with Type 2 diabetes and 6605 HWCs by independent investigators. We used a random-effects model to pool data in the Comprehensive Meta-Analysis Version 2 software. Effect sizes (ESs) were calculated as the standardized mean difference in interleukin concentrations between groups and then transformed into Hedge's g statistic.
Results: Our results revealed higher circulating concentrations in patients with Type 2 diabetes compared with HWCs, including IL-4, IL-6, IL-17, and IL-18. When stratified by BMI subgroups, all patients with Type 2 diabetes displayed elevated IL-6 concentrations compared with HWCs, with OBD patients having the highest ES, followed by OWD and LD. Similar to the overall results, higher interleukin concentrations in different BMI subgroups of patients with Type 2 diabetes were observed compared with HWCs in IL-4 (OWD), IL-17 (LD), and IL-18 (OBD, but not OWD).
Conclusion: Meta-analysis outcomes demonstrated higher circulating concentrations of IL-4, IL-6, IL-17, and IL-18 in patients with Type 2 diabetes, strengthening the clinical evidence that Type 2 diabetes is accompanied by a systemic inflammatory response.
期刊介绍：
Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities.
Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field.
The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.
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