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引用次数: 0
摘要
在Ramón y Cajal对突触识别的开创性贡献之后,神经科学的研究主要集中在它们在神经通讯中的关键作用(神经元学说),忽视了高尔基提出的神经细胞之间非突触相互作用的有趣可能性。最近的跨物种研究揭示了直接细胞通讯的存在,如在不完全细胞分裂过程中形成的细胞间桥(IBs)、新生隧道纳米管(TNTs)和细胞-细胞融合产生的细胞质连接。在这篇综述中,我们深入研究了这些神经细胞之间的非突触通讯模式,描述了它们的形态特征和功能意义。值得注意的是,我们讨论了最近在栉水母和小鼠体内的发现,这些发现为这些细胞间连接的进化功能提供了新的见解。这些发现强调需要考虑在大脑发育和病理生理条件下,细胞质连接在神经细胞通讯中的作用。这篇综述强调了研究这些非突触通信途径对提高我们对后生动物神经通信和进化的理解的重要性。
Beyond synapses: cytoplasmic connections in brain function and evolution.
Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non-synaptic interactions among neural cells. Recent studies across species have unveiled the existence of direct cellular communication through modalities such as intercellular bridges (IBs) formed during incomplete cytokinesis, de novo tunnelling nanotubes (TNTs), and cytoplasmic connections arising from cell-cell fusion. In this review, we delve into these non-synaptic modes of communication between neural cells, describing their morphological features and functional significance. Notably, we discuss recent in vivo findings in ctenophores and in mice which offer fresh insights into the evolutionary functions of these intercellular connections. These findings underscore the need to consider the roles of cytoplasmic connections in neural cell communication during brain development and in pathophysiological conditions. This review highlights the importance of investigating these non-synaptic communication pathways to improve our understanding of neural communication and evolution in metazoans.
期刊介绍:
Biological Reviews is a scientific journal that covers a wide range of topics in the biological sciences. It publishes several review articles per issue, which are aimed at both non-specialist biologists and researchers in the field. The articles are scholarly and include extensive bibliographies. Authors are instructed to be aware of the diverse readership and write their articles accordingly.
The reviews in Biological Reviews serve as comprehensive introductions to specific fields, presenting the current state of the art and highlighting gaps in knowledge. Each article can be up to 20,000 words long and includes an abstract, a thorough introduction, and a statement of conclusions.
The journal focuses on publishing synthetic reviews, which are based on existing literature and address important biological questions. These reviews are interesting to a broad readership and are timely, often related to fast-moving fields or new discoveries. A key aspect of a synthetic review is that it goes beyond simply compiling information and instead analyzes the collected data to create a new theoretical or conceptual framework that can significantly impact the field.
Biological Reviews is abstracted and indexed in various databases, including Abstracts on Hygiene & Communicable Diseases, Academic Search, AgBiotech News & Information, AgBiotechNet, AGRICOLA Database, GeoRef, Global Health, SCOPUS, Weed Abstracts, and Reaction Citation Index, among others.