子宫内暴露于雌激素双酚类似物会增加乳腺组织硬度

IF 2.8 4区 医学 Q2 REPRODUCTIVE BIOLOGY
Jillian M. Poska , Clarissa Wormsbaecher , Brittney M. Cumbia , Madeline R. Price , Marcos Cortes-Medina , Jacob Holter , Shashwat Agarwal , Xiaokui Molly Mo , Jonathan W. Song , Craig J. Burd
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引用次数: 0

摘要

子宫内暴露于雌激素内分泌干扰化合物(EDCs)可增加成年后患乳腺癌的风险。先前的研究表明,雌激素增塑剂双酚A (BPA)在子宫内暴露后会改变啮齿动物模型的乳腺发育,增加乳腺硬度和肿瘤易感性。由于其内分泌干扰特性,BPA已被具有不同激活雌激素受体α能力的结构类似物所取代。然而,子宫内暴露于这些类似物的影响是未知的。在本研究中,我们旨在分析双酚类似物对胶原沉积和乳腺硬度的影响,并表征暴露于这些化合物后乳腺上皮的发育。除双酚S外,所有类似物在25 µg/kg体重剂量下显著增加乳腺硬度,其方式与雌激素活性相关。相比之下,对上皮发育终点的显著影响是有限的,并且没有遵循明确的模式。这些结果增加了关于双酚类似物危害的文献,并支持了这些化合物促进乳腺异常发育的观点。此外,这些数据支持一个模型,即双酚化合物诱导的微环境可能以雌激素依赖的方式促进乳腺癌的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In utero exposure to estrogenic bisphenol analogues increases mammary tissue stiffness
In utero exposures to estrogenic endocrine disrupting compounds (EDCs) can increase breast cancer risk in adulthood. It has previously been shown that the estrogenic plasticizer bisphenol A (BPA) alters development of the mammary gland and increases both mammary gland stiffness and tumor susceptibility in rodent models following in utero exposure. Because of its endocrine disrupting properties, BPA has been substituted with structural analogues with varying abilities to activate estrogen receptor alpha (ERα). However, the impact of in utero exposure to many of these analogues is unknown. In the present study, we aimed to analyze the impact of bisphenol analogues on collagen deposition and mammary gland stiffness and characterize mammary epithelial development following exposure to these compounds. With the exception of bisphenol S, all analogues significantly increased mammary gland stiffness at a 25 µg/kg body weight dose in a manner that correlated to estrogenic activity. In contrast, significant effects on epithelial development endpoints were limited and did not follow a clear pattern. These results add to the growing literature on the hazard of bisphenol analogues and support the idea that these compounds promote abnormal mammary gland development. Furthermore, these data support a model that bisphenol compounds induce a microenvironment that may promote breast cancer development in an estrogen-dependent manner.
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来源期刊
Reproductive toxicology
Reproductive toxicology 生物-毒理学
CiteScore
6.50
自引率
3.00%
发文量
131
审稿时长
45 days
期刊介绍: Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.
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