二卤代烷烃催化还原环化反应

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-06-16 DOI:10.1016/j.tetlet.2025.155705

Sayan Roy , Divya Garg , Christopher Uyeda

引用次数: 0

摘要

镍催化剂利用1,3-二卤丙烷促进烯烃的还原环化生成取代环戊烷。机理研究表明，二卤烷烃的活化是通过卤素原子抽离机制产生碳中心自由基的。总的来说，该方法提供了从简单的无环反应伙伴直接获得饱和环体系的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Catalytic reductive annulation reactions of alkenes using dihaloalkanes

A nickel catalyst promotes the reductive annulation of alkenes using 1,3-dihalopropanes to provide substituted cyclopentanes. Mechanistic studies indicate that activation of the dihaloalkane occurs by a halogen-atom abstraction mechanism to generate a carbon-centered radical. Overall, the method provides direct access to saturated ring-systems from simple acyclic reaction partners.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.