在加拿大环境中，在药物毒性危机期间，拥有一个正规的毒品经销商对获得符合预期的药物检查结果的影响

IF 3.9 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence Pub Date : 2025-06-09 DOI:10.1016/j.drugalcdep.2025.112751

Hannah Esopenko , Brandon D.L. Marshall , Mark Lysyshyn , Cameron Grant , Susan G. Sherman , Evan Wood , Thomas Kerr , Lianping Ti

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引用次数: 0

摘要

背景：不受管制的非法药物供应是加拿大当前毒品危机的一个关键因素，也是一个重大的公共卫生问题。本研究探讨是否有一个定期的毒贩会影响获得与预期一致的药物检查结果的可能性（即，使用药物检查技术检测到个人期望的药物，而不管是否存在其他物质）。方法数据来源于一项横断面研究，该研究于2020年3月至2023年8月在加拿大不列颠哥伦比亚省（BC）的22个危害减少地点进行。这些站点使用傅里叶变换红外光谱（FTIR）和免疫测定条进行药物检查服务。Logistic回归分析检验了拥有固定经销商与获得符合预期的药品检查结果之间的关系。结果共纳入322名参与者，其中268人（83.2%）报告自己是正规的药物经销商，260人（80.7%）的结果与他们最初的药物期望一致。在有固定经销商的人群中，240人（74.8%）100%从经销商处获得药品。在调整混杂因素后，多变量logistic回归分析发现，拥有正规经销商与获得预期药物检查结果之间没有显著关联(校正优势比= 1.10；95%置信区间：0.48 - 2.52，p值= 0.827)。结论：尽管假设常规经销商增加了获得与原始药物预期一致的结果的可能性，但本研究发现没有关联。这些调查结果支持了药物检查、关于不受管制的药物供应不可预测性的教育以及其他必要的减少危害服务在解决加拿大公共卫生危机方面的重要性。

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Impact of having a regular drug dealer on obtaining drug checking results consistent with expectations during a drug toxicity crisis in a Canadian setting

Background

The unregulated illicit drug supply is a key factor in Canada’s ongoing drug crisis and a significant public health concern. This study explores whether having a regular drug dealer impacts the likelihood of obtaining drug checking results consistent with expectations (i.e., the drug the individual expected was detected using drug checking technology, irrespective of other substances present).

Methods

Data were derived from a cross-sectional study, conducted between March 2020 and August 2023, across 22 harm reduction sites in British Columbia (BC), Canada. These sites operate drug checking services using Fourier-transform infrared spectroscopy (FTIR) and immuno-assay strips. Logistic regression analysis examined the relationship between having a regular dealer and obtaining drug checking results consistent with expectations.

Results

A total of 322 participants were included in the study: 268 (83.2 %) reported a regular drug dealer and 260 (80.7 %) obtained results consistent with their primary drug expectation. Among those with a regular dealer, 240 (74.8 %) obtained drugs from them 100 % of the time. After adjusting for confounders, multivariable logistic regression analysis found no significant association between having a regular dealer and obtaining expected drug checking results (adjusted odds ratio = 1.10; 95 % confidence interval: 0.48 – 2.52, p-value = 0.827).

Conclusion

Despite assumptions that a regular dealer increases the likelihood of receiving results consistent with primary drug expectations, this study found no association. These findings support the importance of drug checking, education on the unpredictability of the unregulated drug supply, and other essential harm reduction services in addressing Canada’s public health crisis.

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来源期刊

Drug and alcohol dependence 医学-精神病学

CiteScore

7.40

自引率

7.10%

发文量

409

审稿时长

41 days

期刊介绍： Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.