快速释放锂磷酸盐玻璃促进炎症的消退

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS
Gabriela L Abe*, Linghao Xiao, Jun-Ichi Sasaki, Hirohiko Sakai, Haruaki Kitagawa, Tomoki Kohno, Naoya Funayama and Satoshi Imazato, 
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引用次数: 0

摘要

炎症消退的延迟对组织再生具有灾难性的影响,但局部抗炎信号可以加速这一过程。为了验证这一点,他们制造了基于磷酸盐的生物活性玻璃,在一定的离子浓度下释放抗炎离子锂。锂的释放取决于玻璃配方中铝的摩尔比。释放锂更快的眼镜对活化的巨噬细胞有更大的抗炎作用。这些作用是由于抑制GSK3β活性和促进CD206表达。这项研究证明了抗炎磷酸盐玻璃在解决再生环境中的炎症方面的治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fast Lithium-Releasing Phosphate Glasses Promote the Resolution of Inflammation

Delay in the resolution of inflammation has disastrous implications for tissue regeneration, but local anti-inflammatory signals could accelerate this process. To test this, phosphate-based bioactive glasses were fabricated to release lithium, an anti-inflammatory ion, at a range of ionic concentrations. Lithium release was contingent on the aluminum molar ratio within the glass formulation. Glasses that released lithium faster exerted greater anti-inflammatory effects on activated macrophages. These effects resulted from the inhibition of GSK3β activity and the promotion of CD206 expression. This study demonstrates the therapeutic potential of anti-inflammatory phosphate glasses in resolving inflammation in the regenerative environment.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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