N -烯丙基苯酰胺合成二氟甲基化二氢异喹诺酮类药物的光催化和无氧化剂光诱导自由基级联反应

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-06-14 DOI:10.1002/ejoc.202500214

Bo-Mi Long, Guang-Lin Lu, Zhengshuang Xu, Guo-Kai Liu

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引用次数: 0

摘要

以N -烯丙基苯并胺为原料，以二氟甲基苯氧磷盐（CF2H - PXT+）为原料，制备了二氟甲基化二氢异喹诺酮类化合物。该反应为自由基二氟甲基化/环化级联反应，底物范围广，官能团耐受性好。利用该方法，多种N -烯丙基苯酰胺成功地转化为所需的二氟甲基化二氢异喹诺酮类化合物，收率很高。

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Photocatalyst‐ and Oxidant‐Free Photoinduced Radical Cascade for the Synthesis of Difluoromethylated Dihydroisoquinolones from N‐Allylbenzamides

A mild photocatalyst‐ and oxidant‐free photoinduced reaction for the convenient synthesis of difluoromethylated dihydroisoquinolones from N‐allylbenzamides with a difluoromethyl phenoxathiinium salt (CF2H‐PXT+) is presented, which involves a radical difluoromethylation/cyclization cascade process with broad substrate scope and good functional‐group tolerance. Using this method, a broad range of N‐allylbenzamides were successfully converted to the desired difluoromethylated dihydroisoquinolones in good to high yields.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.