{"title":"山梨果实中甾烷二萜和表皮甾体的研究Gagnep。","authors":"Rong-Qing Yuan, Hai-Yin Wang, Zhou Liu, Lin Jia, Ya-Xuan Ma, Run-Cheng Yan, Shi-Huan Yin, Wen-Chao Tu, Ming Hu, Lin-Fen Ding, Xing-De Wu","doi":"10.1002/cbdv.202501502","DOIUrl":null,"url":null,"abstract":"<p><p>A new clerodane-type diterpenoid, tinosaginoside A (1), and two new ecdysteroids, tinosagisterones A and B (8 and 9), were isolated from the fruits of Tinospora sagittata (Oliv.) Gagnep., as well as and nine previously reported compounds (2-7 and 10-12). The structures and absolute configurations of 1, 8, and 9 were elucidated through comprehensive spectroscopic analyses, including two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and infrared spectroscopy, as well as electronic circular dichroism calculations. Structurally, compound 8 is a rare ecdysteroid featuring a hexadienone unit, and 9 is an unprecedented ecdysteroid characterized by an oxygen bridge between C-2 and C-9. Additionally, compound 7 exhibited moderate inhibitory activity against nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells, with an IC<sub>50</sub> value of 35.78 ± 0.37 µM, compared to the positive control, N<sup>G</sup>-monomethyl-L-arginine, which had an IC<sub>50</sub> value of 40.28 ± 0.48 µM.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01502"},"PeriodicalIF":2.3000,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clerodane Diterpenoids and Ecdysteroids From the Fruits of Tinospora sagittata (Oliv.) Gagnep.\",\"authors\":\"Rong-Qing Yuan, Hai-Yin Wang, Zhou Liu, Lin Jia, Ya-Xuan Ma, Run-Cheng Yan, Shi-Huan Yin, Wen-Chao Tu, Ming Hu, Lin-Fen Ding, Xing-De Wu\",\"doi\":\"10.1002/cbdv.202501502\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A new clerodane-type diterpenoid, tinosaginoside A (1), and two new ecdysteroids, tinosagisterones A and B (8 and 9), were isolated from the fruits of Tinospora sagittata (Oliv.) Gagnep., as well as and nine previously reported compounds (2-7 and 10-12). The structures and absolute configurations of 1, 8, and 9 were elucidated through comprehensive spectroscopic analyses, including two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and infrared spectroscopy, as well as electronic circular dichroism calculations. Structurally, compound 8 is a rare ecdysteroid featuring a hexadienone unit, and 9 is an unprecedented ecdysteroid characterized by an oxygen bridge between C-2 and C-9. Additionally, compound 7 exhibited moderate inhibitory activity against nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells, with an IC<sub>50</sub> value of 35.78 ± 0.37 µM, compared to the positive control, N<sup>G</sup>-monomethyl-L-arginine, which had an IC<sub>50</sub> value of 40.28 ± 0.48 µM.</p>\",\"PeriodicalId\":9878,\"journal\":{\"name\":\"Chemistry & Biodiversity\",\"volume\":\" \",\"pages\":\"e01502\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-06-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry & Biodiversity\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1002/cbdv.202501502\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry & Biodiversity","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/cbdv.202501502","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Clerodane Diterpenoids and Ecdysteroids From the Fruits of Tinospora sagittata (Oliv.) Gagnep.
A new clerodane-type diterpenoid, tinosaginoside A (1), and two new ecdysteroids, tinosagisterones A and B (8 and 9), were isolated from the fruits of Tinospora sagittata (Oliv.) Gagnep., as well as and nine previously reported compounds (2-7 and 10-12). The structures and absolute configurations of 1, 8, and 9 were elucidated through comprehensive spectroscopic analyses, including two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and infrared spectroscopy, as well as electronic circular dichroism calculations. Structurally, compound 8 is a rare ecdysteroid featuring a hexadienone unit, and 9 is an unprecedented ecdysteroid characterized by an oxygen bridge between C-2 and C-9. Additionally, compound 7 exhibited moderate inhibitory activity against nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells, with an IC50 value of 35.78 ± 0.37 µM, compared to the positive control, NG-monomethyl-L-arginine, which had an IC50 value of 40.28 ± 0.48 µM.
期刊介绍：
Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level.
Since 2017, Chemistry & Biodiversity is published in an online-only format.
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