Yu Li, Guangjun Huang, Na Li, Zihao Zhang, Hanwen Zhang, Qian Gao, Zhaokang Cui, Yi Jiang, Yilong Miao
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Multi-omics analysis reveals the molecular mechanism of silibinin rescue the toxic effects of butyl benzyl phthalate on porcine preimplantation embryos
Butyl benzyl phthalate (BBP), a widely used plasticizer and solvent, has raised concerns due to its pervasive presence in the environment and human bodies, prompting worries about its potential health risks. This study aims to uncover the impact of BBP on pre-implantation embryo development and its underlying mechanisms. The experimental results indicate that BBP exposure significantly inhibits the development process of early embryos, reducing the proportion of embryos reaching key formation stages. Through transcriptomic and metabolomic analyses, we found that BBP exposure leads to marked changes in gene expression and metabolite levels associated with mitochondrial function and protein translation, accompanied by structural damage to the endoplasmic reticulum and Golgi apparatus. The study also reveals that BBP may disrupt mitochondrial function through interaction with the mitochondrial membrane protein NDUFA11, thereby inducing oxidative stress and apoptosis. The innovation of this research lies in proposing that silibinin, a natural antioxidant, can effectively alleviate BBP-induced developmental disorders in embryos, offering a new strategy for protecting maternal reproductive health. This work not only provides a scientific basis for understanding the embryotoxicity of BBP but also offers important insights for the health risk assessment and prevention of environmental endocrine disruptors.
期刊介绍:
The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.