染色质折叠的艺术:揭示有丝分裂染色体内DNA的路径。

IF 11.1 Q1 CELL BIOLOGY
Marina Vitoria Gomes, Christian H Haering
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引用次数: 0

摘要

染色质纤维如何折叠成棒状有丝分裂染色体一直是基因组生物学的核心问题。两项新的研究现在以纳米级分辨率重建了人类染色体中的DNA路径,并揭示了环状挤出分子机器如何在有丝分裂开始时将染色质折叠成紧凑的棒状结构。分别使用显微镜或基于测序的方法,两项研究都集中在染色体组织的相似模型上,但在关键的机制细节上有所不同。这些发现进一步挑战了教科书上关于高阶染色质结构的假设,并重新点燃了对活细胞内基因组结构详细理解的追求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The fine art of chromatin folding: Revealing the path of DNA inside mitotic chromosomes.

The fine art of chromatin folding: Revealing the path of DNA inside mitotic chromosomes.

How chromatin fibers fold into rod-shaped mitotic chromosomes has long been a central question in genome biology. Two new studies now reconstruct the path of DNA in human chromosomes at nanoscale resolution and reveal how loop-extruding molecular machines fold chromatin into compact, rod-shaped structures at the onset of mitosis. Using microscopy- or sequencing-based approaches, respectively, both studies converge on similar models of chromosome organization yet differ in key mechanistic details. The findings further challenge textbook hypotheses of higher-order chromatin structures and reignite the quest for a detailed understanding of genome architecture inside living cells.

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