{"title":"亲代自身免疫遗传学与后代1型糖尿病风险","authors":"Anthony M Gacita, Struan F A Grant","doi":"10.1016/j.xgen.2025.100895","DOIUrl":null,"url":null,"abstract":"<p><p>Many children presenting with type 1 diabetes have a family history of the disorder or another autoimmune disease. In this issue of Cell Genomics, Wang et al.<sup>1</sup> use extensive clinical and genetic databases to identify the genetic factors contributing to this familial aggregation and develop polygenic risk scores that predict pediatric type 1 diabetes pathogenesis with high accuracy.</p>","PeriodicalId":72539,"journal":{"name":"Cell genomics","volume":"5 6","pages":"100895"},"PeriodicalIF":11.1000,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Parental autoimmunity genetics and offspring type 1 diabetes risk.\",\"authors\":\"Anthony M Gacita, Struan F A Grant\",\"doi\":\"10.1016/j.xgen.2025.100895\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Many children presenting with type 1 diabetes have a family history of the disorder or another autoimmune disease. In this issue of Cell Genomics, Wang et al.<sup>1</sup> use extensive clinical and genetic databases to identify the genetic factors contributing to this familial aggregation and develop polygenic risk scores that predict pediatric type 1 diabetes pathogenesis with high accuracy.</p>\",\"PeriodicalId\":72539,\"journal\":{\"name\":\"Cell genomics\",\"volume\":\"5 6\",\"pages\":\"100895\"},\"PeriodicalIF\":11.1000,\"publicationDate\":\"2025-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell genomics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.xgen.2025.100895\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell genomics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.xgen.2025.100895","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Parental autoimmunity genetics and offspring type 1 diabetes risk.
Many children presenting with type 1 diabetes have a family history of the disorder or another autoimmune disease. In this issue of Cell Genomics, Wang et al.1 use extensive clinical and genetic databases to identify the genetic factors contributing to this familial aggregation and develop polygenic risk scores that predict pediatric type 1 diabetes pathogenesis with high accuracy.
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