胚胎与偏见：从不同的第一转录印象到共同的发育路径。

IF 11.1 Q1 CELL BIOLOGY

Cell genomics Pub Date : 2025-06-11 DOI:10.1016/j.xgen.2025.100919

Guillaume Giraud Collet, Nicola Festuccia, Pablo Navarro

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引用次数: 0

摘要

着床前哺乳动物的发育在囊胚中达到顶峰，胚胎和胚胎外组织的缔造者居住在囊胚中。然而，从合子基因组激活（ZGA）开始的潜在机制的物种差异仍未得到充分探讨。在这一期的《细胞基因组学》中，Zhang等人1研究了牛胚胎中的RNA Pol II，发现了超级RNA Pol II结构域，这是一种在延迟ZGA物种中促进转录的调控结构。

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Embryo and prejudice: From diverse first transcriptional impressions to a common developmental path.

Pre-implantation mammalian development culminates in the blastocyst, where embryonic and extra-embryonic tissue founders reside. However, species variations in the underlying mechanisms, starting from zygotic genome activation (ZGA), remain underexplored. In this issue of Cell Genomics, Zhang et al.¹ studied RNA Pol II in bovine embryos and discovered super RNA Pol II domains, a regulatory architecture promoting transcription in species with delayed ZGA.

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来源期刊

Cell genomics

CiteScore

7.10

自引率

0.00%

发文量