{"title":"鞘脂与男性生殖健康:它们在精子发生、生育和功能障碍中的作用的叙述综述。","authors":"Mojdeh Parvini, Fatemeh Ghasemian","doi":"10.1007/s43032-025-01898-4","DOIUrl":null,"url":null,"abstract":"<p><p>Sphingolipids are bioactive lipids involved in cellular signaling and structural processes. Recent studies highlight their critical role in spermatogenesis, sperm functionality, and male infertility. Key sphingolipid metabolites, such as ceramide, ceramide-1-phosphate, and sphingosine-1-phosphate, mediate signaling pathways related to apoptosis, proliferation, stress responses, necrosis, inflammation, autophagy, aging, and differentiation. This review aims to summarize recent advancements in understanding the roles of sphingolipids in spermatogenesis, sperm motility, capacitation, the acrosome reaction, and fertilization, as well as their impact on abnormal spermatogenesis, gonadal dysfunction, and infertility. A narrative review was conducted by analyzing relevant literature published primarily between 2000 and 2024, focusing on the involvement of sphingolipids in male reproductive physiology. Sphingolipids regulate various stages of spermatogenesis, including germ cell proliferation, differentiation, and apoptosis, while also modulating critical processes such as sperm maturation, membrane remodeling, and signaling during capacitation and the acrosome reaction. Dysregulation of sphingolipid metabolism contributes to abnormal spermatogenesis, oxidative stress, testicular dysfunction, and impaired sperm functionality, which are linked to male infertility. Additionally, sphingolipids are implicated in sperm-oocyte fusion, further underscoring their essential role in male fertility. Understanding the precise mechanisms of sphingolipid action may offer potential therapeutic targets for treating male infertility. Future research should focus on elucidating these mechanisms and exploring interventions to correct sphingolipid imbalances.</p>","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"2121-2136"},"PeriodicalIF":2.5000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sphingolipids and Male Reproductive Health: A Narrative Review of Their Roles in Spermatogenesis, Fertility, and Dysfunction.\",\"authors\":\"Mojdeh Parvini, Fatemeh Ghasemian\",\"doi\":\"10.1007/s43032-025-01898-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Sphingolipids are bioactive lipids involved in cellular signaling and structural processes. Recent studies highlight their critical role in spermatogenesis, sperm functionality, and male infertility. Key sphingolipid metabolites, such as ceramide, ceramide-1-phosphate, and sphingosine-1-phosphate, mediate signaling pathways related to apoptosis, proliferation, stress responses, necrosis, inflammation, autophagy, aging, and differentiation. This review aims to summarize recent advancements in understanding the roles of sphingolipids in spermatogenesis, sperm motility, capacitation, the acrosome reaction, and fertilization, as well as their impact on abnormal spermatogenesis, gonadal dysfunction, and infertility. A narrative review was conducted by analyzing relevant literature published primarily between 2000 and 2024, focusing on the involvement of sphingolipids in male reproductive physiology. Sphingolipids regulate various stages of spermatogenesis, including germ cell proliferation, differentiation, and apoptosis, while also modulating critical processes such as sperm maturation, membrane remodeling, and signaling during capacitation and the acrosome reaction. Dysregulation of sphingolipid metabolism contributes to abnormal spermatogenesis, oxidative stress, testicular dysfunction, and impaired sperm functionality, which are linked to male infertility. Additionally, sphingolipids are implicated in sperm-oocyte fusion, further underscoring their essential role in male fertility. Understanding the precise mechanisms of sphingolipid action may offer potential therapeutic targets for treating male infertility. Future research should focus on elucidating these mechanisms and exploring interventions to correct sphingolipid imbalances.</p>\",\"PeriodicalId\":20920,\"journal\":{\"name\":\"Reproductive Sciences\",\"volume\":\" \",\"pages\":\"2121-2136\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reproductive Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s43032-025-01898-4\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reproductive Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s43032-025-01898-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/12 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Sphingolipids and Male Reproductive Health: A Narrative Review of Their Roles in Spermatogenesis, Fertility, and Dysfunction.
Sphingolipids are bioactive lipids involved in cellular signaling and structural processes. Recent studies highlight their critical role in spermatogenesis, sperm functionality, and male infertility. Key sphingolipid metabolites, such as ceramide, ceramide-1-phosphate, and sphingosine-1-phosphate, mediate signaling pathways related to apoptosis, proliferation, stress responses, necrosis, inflammation, autophagy, aging, and differentiation. This review aims to summarize recent advancements in understanding the roles of sphingolipids in spermatogenesis, sperm motility, capacitation, the acrosome reaction, and fertilization, as well as their impact on abnormal spermatogenesis, gonadal dysfunction, and infertility. A narrative review was conducted by analyzing relevant literature published primarily between 2000 and 2024, focusing on the involvement of sphingolipids in male reproductive physiology. Sphingolipids regulate various stages of spermatogenesis, including germ cell proliferation, differentiation, and apoptosis, while also modulating critical processes such as sperm maturation, membrane remodeling, and signaling during capacitation and the acrosome reaction. Dysregulation of sphingolipid metabolism contributes to abnormal spermatogenesis, oxidative stress, testicular dysfunction, and impaired sperm functionality, which are linked to male infertility. Additionally, sphingolipids are implicated in sperm-oocyte fusion, further underscoring their essential role in male fertility. Understanding the precise mechanisms of sphingolipid action may offer potential therapeutic targets for treating male infertility. Future research should focus on elucidating these mechanisms and exploring interventions to correct sphingolipid imbalances.
期刊介绍:
Reproductive Sciences (RS) is a peer-reviewed, monthly journal publishing original research and reviews in obstetrics and gynecology. RS is multi-disciplinary and includes research in basic reproductive biology and medicine, maternal-fetal medicine, obstetrics, gynecology, reproductive endocrinology, urogynecology, fertility/infertility, embryology, gynecologic/reproductive oncology, developmental biology, stem cell research, molecular/cellular biology and other related fields.