炎症性肺病:最新进展和挑战的临床和科学回顾。

IF 3.6 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Ahmed A Katamesh, Khaled Almansour, Shimaa M Hassoun, Ossama M Sayed, Mohammed Khaled Bin Break, Randa Mohammed Zaki, Obaid Afzal, Amr Radwan
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引用次数: 0

摘要

炎性肺病,包括慢性阻塞性肺病(COPD)、哮喘、肺结节病和间质性肺病(ILDs),是全球发病率和死亡率的一个重要原因。这些疾病的特点是慢性炎症和组织损伤,导致严重的呼吸系统损害和生活质量下降。本文综述了肺部炎症性疾病的发病机制、临床特点和诊断方法,强调了它们的共同特点和各自的特点。这篇综述综合了目前关于炎症性肺部疾病发生和发展的遗传易感性、环境暴露和免疫反应的文献。它还检查了这些条件的分类和分期,以强调准确诊断和有效管理的重要性。主要发现包括导致疾病发展和进展的众多因素的复杂相互作用,以及支持临床实践的分类和分期系统的分析。通过阐明炎症性肺部疾病的潜在机制和临床特征,本综述旨在为开发新的治疗策略和提高患者预后提供信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inflammatory lung diseases: a clinical and scientific review of the latest advances and challenges.

Inflammatory lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, pulmonary sarcoidosis, and interstitial lung diseases (ILDs), represent a significant cause of morbidity and mortality globally. These conditions are characterized by chronic inflammation and tissue damage, leading to substantial respiratory compromise and impairing quality of life. This review aims to provide a comprehensive overview of pathogenesis, clinical features, and diagnostic approaches for inflammatory lung diseases, emphasizing their shared and distinct characteristics. The review synthesizes current literature on the genetic predisposition, environmental exposures, and immune responses involved in the development and progression of inflammatory lung diseases. It also examines the classification and staging of these conditions to highlight the importance of accurate diagnosis and effective management. Key findings include the complex interplay of numerous factors that contribute to disease development and progression, as well as an analysis of classification and staging systems that support clinical practice. By elucidating the underlying mechanisms and clinical features of inflammatory lung diseases, this review aims to inform the development of novel therapeutic strategies and enhance patient outcomes.

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来源期刊
Pharmacological Reports
Pharmacological Reports 医学-药学
CiteScore
8.40
自引率
0.00%
发文量
91
审稿时长
6 months
期刊介绍: Pharmacological Reports publishes articles concerning all aspects of pharmacology, dealing with the action of drugs at a cellular and molecular level, and papers on the relationship between molecular structure and biological activity as well as reports on compounds with well-defined chemical structures. Pharmacological Reports is an open forum to disseminate recent developments in: pharmacology, behavioural brain research, evidence-based complementary biochemical pharmacology, medicinal chemistry and biochemistry, drug discovery, neuro-psychopharmacology and biological psychiatry, neuroscience and neuropharmacology, cellular and molecular neuroscience, molecular biology, cell biology, toxicology. Studies of plant extracts are not suitable for Pharmacological Reports.
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