乳铁蛋白在女性和新生儿中通过氧化应激、免疫反应和营养支持对抗念珠菌感染中的作用。

IF 4.2 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules Pub Date : 2025-05-31 DOI:10.3390/molecules30112416

Anna Długosz, Joanna Wróblewska, Paweł Kołaczyk, Weronika Wróblewska

{"title":"乳铁蛋白在女性和新生儿中通过氧化应激、免疫反应和营养支持对抗念珠菌感染中的作用。","authors":"Anna Długosz, Joanna Wróblewska, Paweł Kołaczyk, Weronika Wróblewska","doi":"10.3390/molecules30112416","DOIUrl":null,"url":null,"abstract":"Lactoferrin (LF) is a natural glycoprotein with strong antimicrobial, immunomodulatory, and nutritional potential and is widely present in milk and mucosal secretions. This paper aims to review the current knowledge on the application of lactoferrin and its bioactive peptides in the context of fungal infections caused by Candida spp., focusing on newborns and pregnant women as high-risk groups. The multifaceted mechanisms of LF action are discussed, including iron chelation, destabilization of fungal cell membranes, and modulation of the immune response. Additionally, data demonstrating the effectiveness of LF in the prevention and supportive treatment of Candida spp. infections are presented.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 11","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156938/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Role of Lactoferrin in Combating Candida spp. Infections Through Regulation of Oxidative Stress, Immune Response, and Nutritional Support in Women and Newborns.\",\"authors\":\"Anna Długosz, Joanna Wróblewska, Paweł Kołaczyk, Weronika Wróblewska\",\"doi\":\"10.3390/molecules30112416\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Lactoferrin (LF) is a natural glycoprotein with strong antimicrobial, immunomodulatory, and nutritional potential and is widely present in milk and mucosal secretions. This paper aims to review the current knowledge on the application of lactoferrin and its bioactive peptides in the context of fungal infections caused by Candida spp., focusing on newborns and pregnant women as high-risk groups. The multifaceted mechanisms of LF action are discussed, including iron chelation, destabilization of fungal cell membranes, and modulation of the immune response. Additionally, data demonstrating the effectiveness of LF in the prevention and supportive treatment of Candida spp. infections are presented.\",\"PeriodicalId\":19041,\"journal\":{\"name\":\"Molecules\",\"volume\":\"30 11\",\"pages\":\"\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-05-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156938/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecules\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.3390/molecules30112416\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecules","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3390/molecules30112416","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

乳铁蛋白（LF）是一种天然糖蛋白，具有很强的抗菌、免疫调节和营养潜力，广泛存在于牛奶和粘膜分泌物中。本文综述了乳铁蛋白及其生物活性肽在念珠菌真菌感染中的应用现状，重点介绍了新生儿和孕妇这一高危人群。讨论了LF作用的多方面机制，包括铁螯合，真菌细胞膜的不稳定和免疫反应的调节。此外，数据显示了LF在预防和支持治疗念珠菌感染方面的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The Role of Lactoferrin in Combating Candida spp. Infections Through Regulation of Oxidative Stress, Immune Response, and Nutritional Support in Women and Newborns.

Lactoferrin (LF) is a natural glycoprotein with strong antimicrobial, immunomodulatory, and nutritional potential and is widely present in milk and mucosal secretions. This paper aims to review the current knowledge on the application of lactoferrin and its bioactive peptides in the context of fungal infections caused by Candida spp., focusing on newborns and pregnant women as high-risk groups. The multifaceted mechanisms of LF action are discussed, including iron chelation, destabilization of fungal cell membranes, and modulation of the immune response. Additionally, data demonstrating the effectiveness of LF in the prevention and supportive treatment of Candida spp. infections are presented.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.