Xiaoling Xie, Xin Sun, Wanming Lin, Xiaofeng Yang, Ruicong Wang
{"title":"具有可控产氧行为的过氧化钙/聚乙二醇@二氧化硅纳米颗粒的制备与性能","authors":"Xiaoling Xie, Xin Sun, Wanming Lin, Xiaofeng Yang, Ruicong Wang","doi":"10.3390/ma18112568","DOIUrl":null,"url":null,"abstract":"<p><p>The hypoxic microenvironment is the main challenge for the repair of damaged tissue, and oxygen supply is an effective means of alleviating hypoxia. In this study, a series of core-shell-structured calcium peroxide/poly(ethylene glycol)@silica (CPO@SiO<sub>2</sub>) nanoparticles are prepared to generate oxygen steadily. The size of the CPO@SiO<sub>2</sub> nanoparticles ranges from 205 to 302 nm, with a narrow polydispersity index (PDI). In this system, the nano CPO core acts as the oxygen source to improve hypoxia, while the SiO<sub>2</sub> shell layer serves as the physical barrier to control the oxygen-generating rate and improve biocompatibility. The results suggest that the thickness of the SiO<sub>2</sub> shell layer can be modulated by adjusting the amount of tetraethyl orthosilicate (TEOS). The prepared CPO@SiO<sub>2</sub> nanoparticles show a controlled oxygen-generating rate. Moreover, compared with CPO, the CPO@SiO<sub>2</sub> nanoparticles have good biocompatibility. To assess the modulating effects for the hypoxic microenvironment, L929 cells are co-cultured with CPO@ SiO<sub>2</sub> nanoparticles under hypoxia. The results suggest that the CPO@ SiO<sub>2</sub> nanoparticles can support the cell survival under hypoxia. Moreover, they can effectively decrease oxidative stress damage and reduce the levels of expression of hypoxia-induced superoxide dismutase (SOD) and malondialdehyde (MDA). Therefore, the prepared CPO@ SiO<sub>2</sub> nanoparticles with controlled oxygen-generating properties could be a promising candidate for repairing damaged tissue.</p>","PeriodicalId":18281,"journal":{"name":"Materials","volume":"18 11","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156953/pdf/","citationCount":"0","resultStr":"{\"title\":\"Preparation and Properties of Calcium Peroxide/Poly(ethylene glycol)@Silica Nanoparticles with Controlled Oxygen-Generating Behaviors.\",\"authors\":\"Xiaoling Xie, Xin Sun, Wanming Lin, Xiaofeng Yang, Ruicong Wang\",\"doi\":\"10.3390/ma18112568\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The hypoxic microenvironment is the main challenge for the repair of damaged tissue, and oxygen supply is an effective means of alleviating hypoxia. In this study, a series of core-shell-structured calcium peroxide/poly(ethylene glycol)@silica (CPO@SiO<sub>2</sub>) nanoparticles are prepared to generate oxygen steadily. The size of the CPO@SiO<sub>2</sub> nanoparticles ranges from 205 to 302 nm, with a narrow polydispersity index (PDI). In this system, the nano CPO core acts as the oxygen source to improve hypoxia, while the SiO<sub>2</sub> shell layer serves as the physical barrier to control the oxygen-generating rate and improve biocompatibility. The results suggest that the thickness of the SiO<sub>2</sub> shell layer can be modulated by adjusting the amount of tetraethyl orthosilicate (TEOS). The prepared CPO@SiO<sub>2</sub> nanoparticles show a controlled oxygen-generating rate. Moreover, compared with CPO, the CPO@SiO<sub>2</sub> nanoparticles have good biocompatibility. To assess the modulating effects for the hypoxic microenvironment, L929 cells are co-cultured with CPO@ SiO<sub>2</sub> nanoparticles under hypoxia. The results suggest that the CPO@ SiO<sub>2</sub> nanoparticles can support the cell survival under hypoxia. Moreover, they can effectively decrease oxidative stress damage and reduce the levels of expression of hypoxia-induced superoxide dismutase (SOD) and malondialdehyde (MDA). Therefore, the prepared CPO@ SiO<sub>2</sub> nanoparticles with controlled oxygen-generating properties could be a promising candidate for repairing damaged tissue.</p>\",\"PeriodicalId\":18281,\"journal\":{\"name\":\"Materials\",\"volume\":\"18 11\",\"pages\":\"\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-05-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156953/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.3390/ma18112568\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.3390/ma18112568","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Preparation and Properties of Calcium Peroxide/Poly(ethylene glycol)@Silica Nanoparticles with Controlled Oxygen-Generating Behaviors.
The hypoxic microenvironment is the main challenge for the repair of damaged tissue, and oxygen supply is an effective means of alleviating hypoxia. In this study, a series of core-shell-structured calcium peroxide/poly(ethylene glycol)@silica (CPO@SiO2) nanoparticles are prepared to generate oxygen steadily. The size of the CPO@SiO2 nanoparticles ranges from 205 to 302 nm, with a narrow polydispersity index (PDI). In this system, the nano CPO core acts as the oxygen source to improve hypoxia, while the SiO2 shell layer serves as the physical barrier to control the oxygen-generating rate and improve biocompatibility. The results suggest that the thickness of the SiO2 shell layer can be modulated by adjusting the amount of tetraethyl orthosilicate (TEOS). The prepared CPO@SiO2 nanoparticles show a controlled oxygen-generating rate. Moreover, compared with CPO, the CPO@SiO2 nanoparticles have good biocompatibility. To assess the modulating effects for the hypoxic microenvironment, L929 cells are co-cultured with CPO@ SiO2 nanoparticles under hypoxia. The results suggest that the CPO@ SiO2 nanoparticles can support the cell survival under hypoxia. Moreover, they can effectively decrease oxidative stress damage and reduce the levels of expression of hypoxia-induced superoxide dismutase (SOD) and malondialdehyde (MDA). Therefore, the prepared CPO@ SiO2 nanoparticles with controlled oxygen-generating properties could be a promising candidate for repairing damaged tissue.
期刊介绍：
Materials (ISSN 1996-1944) is an open access journal of related scientific research and technology development. It publishes reviews, regular research papers (articles) and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Materials provides a forum for publishing papers which advance the in-depth understanding of the relationship between the structure, the properties or the functions of all kinds of materials. Chemical syntheses, chemical structures and mechanical, chemical, electronic, magnetic and optical properties and various applications will be considered.
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