慢性组织细胞性绒毛间炎胎盘绒毛间血中母体免疫细胞的研究：未来的研究方向。

IF 2.8 4区医学 Q3 IMMUNOLOGY

Immunology letters Pub Date : 2025-06-10 DOI:10.1016/j.imlet.2025.107053

Q. Lu , L.E. van der Meeren , M. Eikmans , M.L.P. van der Hoorn

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引用次数: 0

摘要

慢性组织细胞性绒毛间炎（CHI）与不良妊娠结局相关，并导致以绒毛间间隙母髓细胞为特征的胎盘炎症。这个绒毛间空间是母胎界面的一部分，为绒毛间血液和胎盘成分之间的免疫串扰提供了一个独特的微环境。CHI的病理生理途径尚不清楚。在这里，我们对目前关于CHI的知识、绒毛间采血方法和健康足月妊娠绒毛间间隙的免疫细胞特征进行了综述。我们强调，对CHI胎盘绒毛间血中母体免疫细胞的详细表型和功能研究有望为更好地了解疾病的病因提供帮助。

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Maternal immune cell investigation from intervillous blood of placentas with chronic histiocytic intervillositis: Directions for future research

Chronic histiocytic intervillositis (CHI) is associated with adverse pregnancy outcome and results in placental inflammation characterized by maternal myeloid cells within the intervillous space. This intervillous space is part of the maternal-fetal interface, which provides a unique microenvironment for the immunologic crosstalk between intervillous blood and placental components. The pathophysiologic pathways of CHI are still unclear. Here, we conduct a narrative review on the current knowledge about CHI, intervillous blood sampling methods, and immune cell characteristics in the intervillous space of healthy term pregnancy. We highlight that the detailed phenotype and functional investigation of maternal immune cells from intervillous blood of placentas with CHI is expected to provide better understanding of the etiology of disease.

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来源期刊

Immunology letters 医学-免疫学

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

44 days

期刊介绍： Immunology Letters provides a vehicle for the speedy publication of experimental papers, (mini)Reviews and Letters to the Editor addressing all aspects of molecular and cellular immunology. The essential criteria for publication will be clarity, experimental soundness and novelty. Results contradictory to current accepted thinking or ideas divergent from actual dogmas will be considered for publication provided that they are based on solid experimental findings. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.