麻疯树全株中具有生物活性的迷迭香和足carpane二萜类化合物。

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2025-06-13 DOI:10.1002/cbdv.202500956

Zhong-Dan Liang, Yan-Ling Tang, Chao-Jun Li, Yan-Fang Li, Muhammad Aurang Zeb, Xue-Wen Wu, Qi Li, Bo Li, Xiao-Li Li, Xing-Jie Zhang, Wei-Lie Xiao

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引用次数: 0

摘要

从麻疯树（Jatropha curcas L.）全株中分离得到1个既往未见的迷香二萜类化合物(1)和13个已知化合物（2 ~ 14），通过核磁共振计算结合DP4+概率分析确定其相对构型1，再通过ECD计算确定其绝对构型（AC）。最后的结构通过单晶x射线衍射进一步证实。生物学试验表明，化合物5和14对NLRP3炎性体具有抑制作用，IC50值分别为8.1±0.3和9.7±0.4µM。进一步研究表明，化合物5具有明显的抑制焦亡作用。

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Bioactive Rosane and Podocarpane Diterpenoids From the Whole Plant of Jatropha curcas L.

One previously undescribed rosane diterpenoid (1) and 13 known ones (2-14) were isolated from the whole plant of Jatropha curcas L. The relative configuration 1 was determined by NMR calculation combined with DP4+ probability analysis, and its absolute configuration (AC) was further determined by ECD calculation. The final structure was further confirmed by single crystal x-ray diffraction. The biological testing revealed that compounds 5 and 14 possessed inhibitory effects on NLRP3 inflammasome with IC₅₀ values of 8.1 ± 0.3 and 9.7 ± 0.4 µM. Further investigation exhibited that compound 5 has an obvious effect on inhibiting pyroptosis.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.