给药的美洛昔康微丸减轻泌乳小牛疼痛的某些指标。

IF 2.7 2区 农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Animals Pub Date : 2025-06-03 DOI:10.3390/ani15111641
Tiarna Scerri, Sabrina Lomax, Peter Thomson, Benjamin Kimble, Peter White, Merran Govendir, Cameron Clark, Dominique Van der Saag
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引用次数: 0

摘要

脱毛是一种饲养方法,会给小牛带来疼痛和不适。作为一个突出的福利问题,现在对小牛进行镇痛治疗,如注射非甾体抗炎药(NSAID)是标准做法。美洛昔康是一种常用的非甾体抗炎药,因为它可以在拔除后长达44小时内缓解疼痛。然而,由于症状可以持续长达两周,因此假设更长时间的镇痛治疗将比传统注射促进更好的福利结果。这项研究测试了一种新的治疗方法,即在7天的时间里,给断奶的小牛喂食含有美洛昔康的谷物颗粒。与常规注射相比,在7天的喂养期内,颗粒治疗的角部炎症水平较低。在喂食期间和之后,服用颗粒的小牛也表现出更少的疼痛特异性和更积极的社会特异性行为。总之,这些结果表明,长期服用美洛昔康引起的较低水平的炎症在减轻疼痛和维持脱胎小牛的情感方面具有积极作用。以建立持续脱芽治疗作为新的行业标准为目标,未来的研究将侧重于更大规模的结果可重复性和最大限度地提高治疗的实用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Medicated Meloxicam Pellets Reduce Some Indicators of Pain in Disbudded Dairy Calves.

Disbudding is a husbandry practice that causes pain and discomfort to calves. As a prominent welfare concern, it is now standard practice for calves to be given analgesic treatment such as a nonsteroidal anti-inflammatory drug (NSAID) injection. Meloxicam is a commonly used NSAID as it provides pain relief for up to 44 h following disbudding. However, since symptoms can persist for up to two weeks, it was hypothesised that more prolonged analgesic treatment would promote better welfare outcomes than the conventional injection. This study tested a novel treatment whereby disbudded calves were fed grain-based pellets medicated with meloxicam over a 7-day period. Lower levels of horn site inflammation were observed for the pellet treatment across the 7-day feeding period in comparison to the conventional injection. The pellet treatment calves also exhibited less pain-specific and more positive social-specific behaviours during and beyond the feeding period. Together, these results suggest that lower levels of inflammation enacted by prolonged meloxicam administration have an active role in reducing pain and maintaining the affectivity of disbudded calves. With the goal of establishing sustained disbudding treatment as a new industry standard, future research will focus on larger-scale results reproducibility and maximising treatment practicality.

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来源期刊
Animals
Animals Agricultural and Biological Sciences-Animal Science and Zoology
CiteScore
4.90
自引率
16.70%
发文量
3015
审稿时长
20.52 days
期刊介绍: Animals (ISSN 2076-2615) is an international and interdisciplinary scholarly open access journal. It publishes original research articles, reviews, communications, and short notes that are relevant to any field of study that involves animals, including zoology, ethnozoology, animal science, animal ethics and animal welfare. However, preference will be given to those articles that provide an understanding of animals within a larger context (i.e., the animals'' interactions with the outside world, including humans). There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental details and/or method of study, must be provided for research articles. Articles submitted that involve subjecting animals to unnecessary pain or suffering will not be accepted, and all articles must be submitted with the necessary ethical approval (please refer to the Ethical Guidelines for more information).
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