进化的命运：猫心源性动脉血栓栓塞的发病机制和治疗的新视角。

IF 2.7 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animals Pub Date : 2025-06-01 DOI:10.3390/ani15111630

Natasha S Yeh, Meg Shaverdian, Ronald H L Li

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引用次数: 0

摘要

猫心源性动脉血栓栓塞（FATE）仍然是猫心肌病最具破坏性的并发症之一，具有高死亡率和复发率。尽管它具有临床重要性，但我们对FATE的发病机制和最佳治疗策略的理解仍然存在显著的知识差距。我们的综述旨在通过全面概述目前对FATE的理解，包括疾病机制、危险因素、新兴诊断方法和预防策略，来解决这些差距。重要的是，我们确定了关键领域，如免疫血栓形成、促凝血小板、血小板异质性和纤维蛋白溶解改变，未来的研究可能会产生新的生物标志物和治疗靶点，以改善受影响猫患者的预后。

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Evolving FATE: A New Lens on the Pathogenesis and Management of Feline Cardiogenic Arterial Thromboembolism.

Feline cardiogenic arterial thromboembolism (FATE) remains one of the most devastating complications of feline cardiomyopathies, with high mortality and recurrence rates. Despite its clinical importance, significant knowledge gaps persist in our understanding of FATE's pathogenesis and optimal management strategies. Our review aims to address these gaps by providing a comprehensive overview of the current understanding of FATE, including disease mechanisms, risk factors, emerging diagnostics, and preventative strategies. Importantly, we identify key areas such as immunothrombosis, procoagulant platelets, platelet heterogeneity, and altered fibrinolysis where future research may yield novel biomarkers and therapeutic targets to improve outcomes in affected feline patients.

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来源期刊

Animals Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

4.90

自引率

16.70%

发文量

3015

审稿时长

20.52 days

期刊介绍： Animals (ISSN 2076-2615) is an international and interdisciplinary scholarly open access journal. It publishes original research articles, reviews, communications, and short notes that are relevant to any field of study that involves animals, including zoology, ethnozoology, animal science, animal ethics and animal welfare. However, preference will be given to those articles that provide an understanding of animals within a larger context (i.e., the animals'' interactions with the outside world, including humans). There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental details and/or method of study, must be provided for research articles. Articles submitted that involve subjecting animals to unnecessary pain or suffering will not be accepted, and all articles must be submitted with the necessary ethical approval (please refer to the Ethical Guidelines for more information).