调节少突胶质祖细胞迁移的因素:从发育到髓鞘再生。

IF 5.1 2区 医学 Q1 NEUROSCIENCES
Glia Pub Date : 2025-10-01 Epub Date: 2025-06-13 DOI:10.1002/glia.70051
Ming-Xuan Cao, Johannes Boltze, Shen Li
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引用次数: 0

摘要

中枢神经系统(CNS)中的少突胶质细胞祖细胞(OPCs)具有增殖、迁移和分化为少突胶质细胞的能力。OPCs对发育期间轴突的髓鞘形成和成年期损伤后的再髓鞘形成至关重要。OPCs还在促进血管生成、神经保护和免疫调节中发挥重要作用,这使其成为许多中枢神经系统疾病,特别是脱髓鞘疾病的再生方法的相关因素。OPC迁移在神经发育和再生过程中是重要的,因此受到多种细胞内和细胞外因素的调节。识别这些因素有助于优化调控OPC迁移,从而提高治疗效果。该领域是当前的研究热点,新发现不断涌现。本文综述了控制OPC迁移的调控因子的研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Factors Regulating Oligodendrocyte Progenitor Cell Migration: From Development to Remyelination.

Oligodendrocyte progenitor cells (OPCs) in the central nervous system (CNS) are capable of proliferating, migrating, and differentiating into oligodendrocytes. OPCs are crucial for the myelination of axons during development and remyelination after injury in adulthood. OPCs also play important roles in promoting angiogenesis, neurotrophy, and immunomodulation, which makes them a relevant element of regenerative approaches for many CNS diseases, especially demyelinating ones. OPC migration is important during neurodevelopment and regeneration, and as such is regulated by a multitude of intracellular and extracellular factors. Identifying these factors will facilitate the optimized regulation of OPC migration and thus enhance therapeutic effects. This field is a current research hotspot, and new findings are constantly emerging. Here, we comprehensively review research progress on the regulatory factors that control OPC migration.

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来源期刊
Glia
Glia 医学-神经科学
CiteScore
13.10
自引率
4.80%
发文量
162
审稿时长
3-8 weeks
期刊介绍: GLIA is a peer-reviewed journal, which publishes articles dealing with all aspects of glial structure and function. This includes all aspects of glial cell biology in health and disease.
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