基于右旋糖酐的可食用膜的制备,用于胶原-生物活性玻璃复合物的结肠靶向口服递送

IF 1.9 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Manjot Kaur, Deenan Santhiya
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引用次数: 0

摘要

口服给药的主要缺点是可得性差。这通常导致口服给药后需要更高剂量的制剂以达到治疗血浆浓度。这项工作的重点是骨营养微量营养素的靶向递送,这在量化给予相关个体的剂量量方面起着重要作用。在本研究中,以糊精为基础的可食用薄膜的制备和表征,用于结肠靶向口服胶原蛋白和微量营养素,以促进骨骼健康。对于膜的构成,生物活性玻璃网络的矿化是在胶原基质中与维生素d一起进行的。然后,将该膜夹在葡聚糖膜之间,以促进肠道靶向递送。研究了所形成的薄膜在胃液和肠液中的流动行为。流变学研究描绘的粘弹性性质的薄膜在胃肠道。SDS-PAGE图谱证实胶原蛋白的结肠靶向递送。所构建的膜被证明具有生物相容性,细胞存活率超过80±4%,分解研究显示其生物降解率超过80±4%。因此,上述夹层膜被证明是骨健康应用中营养物质靶向递送的潜在载体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fabrication of Dextran-Based Edible Film for Colon-Targeted Delivery of Collagen-Bioactive Glass Complex Through Oral Route

Oral drug delivery comes with the major drawback of poor availability. This usually leads to the formulation of higher doses to reach the therapeutic plasma concentration after oral administration. This work focuses on the targeted delivery of micronutrients for bone nutrition, which plays a significant role in quantifying the amount of dosage to be given to the concerned individual. In this study, the fabrication and characterization of dextran-based edible film for the colon-targeted oral delivery of collagen and micronutrients is carried out for bone health. For film constitution, mineralization of the bioactive glass network is carried out in a collagen matrix along with vitamin D. This film is then sandwiched between the dextran film to facilitate intestinal targeted delivery. The flow behavior of the formed film is studied in gastric fluid and intestinal fluid. The rheological studies depicting the visco-elastic nature of the film in GI tract. SDS-PAGE profile confirms the colon-targeted delivery of collagen. The constructed film proves to be biocompatible, showcasing more than 80 ± 4% cell viability and disintegration studies showcasing 80 ± 4% confirms its biodegradation. Thus, the aforementioned sandwiched film proves to be a potential carrier of the targeted delivery of nutrients for bone health applications.

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来源期刊
ChemistrySelect
ChemistrySelect Chemistry-General Chemistry
CiteScore
3.30
自引率
4.80%
发文量
1809
审稿时长
1.6 months
期刊介绍: ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.
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