颈动脉斑块内新生血管与冠状动脉粥样硬化斑块相关，冠状动脉内光学相干断层扫描检测易损性

IF 3.2 2区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

International journal of cardiology Pub Date : 2025-06-11 DOI:10.1016/j.ijcard.2025.133495

Yingying Liu , Xin Fu , Xin Ai, Guangyin Li, Chun Wang, Piao Wu, Haizhuo Yu, Shuangquan Jiang

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引用次数: 0

摘要

目的探讨超声造影（CEUS）测量颈动脉斑块内新生血管（IPN）与光学相干断层扫描（OCT）评估冠心病（CAD）患者斑块易损性之间的关系。方法将131例受试者分为易损冠状动脉斑块组（VP）和非易损冠状动脉斑块组（non VP）。超声造影中采用半定量和定量评价颈动脉IPN，以最大斑块高度（MPH）的颈动脉斑块进行分析。采用Logistic回归评价冠状动脉斑块易损性的危险因素。结果根据10月斑块易损特点将患者分为VP组（N = 92）和非VP组（N = 39）。在CEUS中，两组患者的IPN评分差异有统计学意义（P = 0.003）。超声造影定量分析显示颈动脉斑块峰值强度（PI）(28.65±4.21 dB vs. 22.51±3.13 dB, P <；0.001),增强强度(EI)(24.91±4.05 dB和19.20±3.17 dB, P & lt;斑块/管腔增强强度比（P/L比）(0.32±0.08∶0.24±0.09,P <；0.001)， VP组高于非VP组。多因素logistic回归分析显示，EI （OR = 1.473, 95% CI:(1.039 ~ 2.086)）和P/L比（OR = 1.109, 95% CI:(1.024 ~ 1.2)）与冠脉斑块易损性密切相关。结论颈动脉斑块超声造影参数与斑块易损性相关。超声造影作为一种无创检查，可以为CAD患者的风险分层和临床治疗提供有价值的信息。

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Carotid Intraplaque neovascularization correlates with coronary atherosclerotic plaque, vulnerability detected by intracoronary optical coherence tomography

Objective

The aim of the present study was to evaluate the relationships between carotid intraplaque neovascularization (IPN) measured by contrast-enhanced ultrasound (CEUS) and culprit coronary artery plaque vulnerability evaluated by optical coherence tomography (OCT) in patients with coronary artery disease (CAD).

Methods

A total of 131 participants were divided into the vulnerable coronary plaque (VP) and non-vulnerable coronary plaque (non-VP) group. The plaque vulnerability was determined by OCT. In CEUS, carotid IPN was assessed by semi-quantitative and quantitative evaluation, the carotid plaque with the maximum plaque height (MPH) was used for analysis. Logistic regression was used to assess risk factors of coronary plaque vulnerability.

Results

Patients were classified into VP group (N = 92) and non-VP group (N = 39) according to the features of plaque vulnerability in OCT. In CEUS, the IPN score between the two groups was significant different(P = 0.003). Quantitative analysis of CEUS showed that carotid plaque peak intensity (PI) (28.65 ± 4.21 dB vs. 22.51 ± 3.13 dB, P < 0.001), enhancement intensity (EI) (24.91 ± 4.05 dB vs. 19.20 ± 3.17 dB, P < 0.001), and enhanced intensity ratio of plaque/lumen (P/L ratio) (0.32 ± 0.08 vs. 0.24 ± 0.09, P < 0.001) were higher in VP group than non-VP group. Multivariate logistic regression analyses demonstrated that EI (OR = 1.473, 95 %CI: (1.039–2.086)) and P/L ratio (OR = 1.109, 95 %CI: (1.024–1.2)) were strongly associated with coronary plaque vulnerability.

Conclusion

The CEUS parameters of carotid plaques is correlated with coronary plaque vulnerability. As a non-invasive examination, CEUS may provide valuable information to advance risk stratification and clinical treatment in patients with CAD.

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来源期刊

International journal of cardiology 医学-心血管系统

CiteScore

6.80

自引率

5.70%

发文量

758

审稿时长

44 days

期刊介绍： The International Journal of Cardiology is devoted to cardiology in the broadest sense. Both basic research and clinical papers can be submitted. The journal serves the interest of both practicing clinicians and researchers. In addition to original papers, we are launching a range of new manuscript types, including Consensus and Position Papers, Systematic Reviews, Meta-analyses, and Short communications. Case reports are no longer acceptable. Controversial techniques, issues on health policy and social medicine are discussed and serve as useful tools for encouraging debate.