从矢状木的块根中提取的氯烷呋喃二萜Gagnep。及其α-葡萄糖苷酶抑制活性

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-06-12 DOI:10.1016/j.fitote.2025.106680

Zhang-Juan Li , Ming Hu , Rong-Qing Yuan, Ling Jia, Ya-Xuan Ma, Zhou Liu, Meng-Xia Shen, Gui-Fa Zhu, Gan-peng Li, Xing-De Wu

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引用次数: 0

摘要

四种先前未被描述的氯罗丹型呋喃二萜，tinosagins A-D(1-4)，从Tinospora sagittata （Oliv.）的块根中分离得到。Gagnep。，以及11种已知化合物（5-15）。通过广泛的光谱分析、电子圆二色性计算和单晶x射线衍射确定了它们的结构。化合物1是具有7,8-环氧基的罕见氯烷二萜。所有分离得到的化合物对α-葡萄糖苷酶的抑制活性进行了评价。结果表明，1和2具有明显的α-葡萄糖苷酶抑制活性，IC50值分别为31.83±0.83和47.35±0.96 μM。

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Clerodane furanoditerpenoids from the tuberous roots of Tinospora sagittata (Oliv.) Gagnep. and their α-glucosidase inhibitory activity

Four previously undescribed clerodane-type furanoditerpenoids, tinosagins A-D (1–4), were isolated from the tuberous roots of Tinospora sagittata (Oliv.) Gagnep., together with 11 known compounds (5–15). Their structures were determined by extensive spectroscopic analyses, electronic circular dichroism calculation, and single-crystal X-ray diffraction. Compound 1 was an unusual clerodane diterpenoid with 7,8-epoxy unit. All isolated compounds were evaluated for their inhibitory activity against α-glucosidase. The results indicated that 1 and 2 exhibited notable α-glucosidase inhibitory activity, with the IC₅₀ values of 31.83 ± 0.83 and 47.35 ± 0.96 μM, respectively.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.