Taline Canto Tristão , Mariana Abou Mourad Ferreira , Pedro Sousa de Almeida Júnior , Luiz Guilherme Schmidt Castellani , Manuela Negrelli Brunetti , Edward C. Jones-López , Kevin P. Fennelly , Michael R. Barer , Carlos Henrique Fantecelle , Saulo Almeida Morellato , David Jamil Hadad , Jerrold J. Ellner , Reynaldo Dietze , Moisés Palaci
{"title":"肺结核患者咳嗽产生的传染性气溶胶的动态","authors":"Taline Canto Tristão , Mariana Abou Mourad Ferreira , Pedro Sousa de Almeida Júnior , Luiz Guilherme Schmidt Castellani , Manuela Negrelli Brunetti , Edward C. Jones-López , Kevin P. Fennelly , Michael R. Barer , Carlos Henrique Fantecelle , Saulo Almeida Morellato , David Jamil Hadad , Jerrold J. Ellner , Reynaldo Dietze , Moisés Palaci","doi":"10.1016/j.jaerosci.2025.106633","DOIUrl":null,"url":null,"abstract":"<div><div>Tuberculosis (TB) is an ancient disease transmitted through aerosols frequently generated by coughing and it is still unknown whether there is variability in cough aerosol output throughout the day and whether this may impact patients’ infectivity categorization. To study the dynamic of infectious aerosols generated by cough, we conducted a cross-sectional study on pulmonary TB patients (n = 16) who had their cough-generated aerosols sampled twice daily for two consecutive days for the Cough Aerosol Sampling System (CASS) assay. Most patients were classified as Variable Low Producers and Variable High Producers (n = 10; 62.5 %), followed by Negative Producers (n = 4; 25 %) and Consistent Producers (n = 2; 12.5 %). Additionally, most recovered bacilli (88.7 %) within a respiratory aerosol size range. Although the time of collection did not appear to impact on aerosol infectivity, performing CASS with multiple samples allowed for more accurate detection and distinction among aerosol producers.</div></div>","PeriodicalId":14880,"journal":{"name":"Journal of Aerosol Science","volume":"189 ","pages":"Article 106633"},"PeriodicalIF":2.9000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dynamic of infectious aerosols generated by cough from patients with pulmonary tuberculosis\",\"authors\":\"Taline Canto Tristão , Mariana Abou Mourad Ferreira , Pedro Sousa de Almeida Júnior , Luiz Guilherme Schmidt Castellani , Manuela Negrelli Brunetti , Edward C. Jones-López , Kevin P. Fennelly , Michael R. Barer , Carlos Henrique Fantecelle , Saulo Almeida Morellato , David Jamil Hadad , Jerrold J. Ellner , Reynaldo Dietze , Moisés Palaci\",\"doi\":\"10.1016/j.jaerosci.2025.106633\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Tuberculosis (TB) is an ancient disease transmitted through aerosols frequently generated by coughing and it is still unknown whether there is variability in cough aerosol output throughout the day and whether this may impact patients’ infectivity categorization. To study the dynamic of infectious aerosols generated by cough, we conducted a cross-sectional study on pulmonary TB patients (n = 16) who had their cough-generated aerosols sampled twice daily for two consecutive days for the Cough Aerosol Sampling System (CASS) assay. Most patients were classified as Variable Low Producers and Variable High Producers (n = 10; 62.5 %), followed by Negative Producers (n = 4; 25 %) and Consistent Producers (n = 2; 12.5 %). Additionally, most recovered bacilli (88.7 %) within a respiratory aerosol size range. Although the time of collection did not appear to impact on aerosol infectivity, performing CASS with multiple samples allowed for more accurate detection and distinction among aerosol producers.</div></div>\",\"PeriodicalId\":14880,\"journal\":{\"name\":\"Journal of Aerosol Science\",\"volume\":\"189 \",\"pages\":\"Article 106633\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-06-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Aerosol Science\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0021850225001107\",\"RegionNum\":3,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Aerosol Science","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0021850225001107","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
Dynamic of infectious aerosols generated by cough from patients with pulmonary tuberculosis
Tuberculosis (TB) is an ancient disease transmitted through aerosols frequently generated by coughing and it is still unknown whether there is variability in cough aerosol output throughout the day and whether this may impact patients’ infectivity categorization. To study the dynamic of infectious aerosols generated by cough, we conducted a cross-sectional study on pulmonary TB patients (n = 16) who had their cough-generated aerosols sampled twice daily for two consecutive days for the Cough Aerosol Sampling System (CASS) assay. Most patients were classified as Variable Low Producers and Variable High Producers (n = 10; 62.5 %), followed by Negative Producers (n = 4; 25 %) and Consistent Producers (n = 2; 12.5 %). Additionally, most recovered bacilli (88.7 %) within a respiratory aerosol size range. Although the time of collection did not appear to impact on aerosol infectivity, performing CASS with multiple samples allowed for more accurate detection and distinction among aerosol producers.
期刊介绍:
Founded in 1970, the Journal of Aerosol Science considers itself the prime vehicle for the publication of original work as well as reviews related to fundamental and applied aerosol research, as well as aerosol instrumentation. Its content is directed at scientists working in engineering disciplines, as well as physics, chemistry, and environmental sciences.
The editors welcome submissions of papers describing recent experimental, numerical, and theoretical research related to the following topics:
1. Fundamental Aerosol Science.
2. Applied Aerosol Science.
3. Instrumentation & Measurement Methods.