亚临床肺结核与活动性肺结核的特征比较：一项回顾性队列研究

IF 1.9 Q3 INFECTIOUS DISEASES

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Pub Date : 2025-05-20 DOI:10.1016/j.jctube.2025.100535

Aiping Zhang , Wenjie Wang , Zijian Wang, Haoyu Sheng, Jianghua Yang

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引用次数: 0

摘要

背景亚临床肺结核（SPTB）知之甚少，其诊断仍然具有挑战性。目的分析SPTB的实验室检测结果，提高临床认识，帮助早期诊断。方法对某大学医院收治的138例SPTB患者与活动性肺结核（APTB）（140例）和健康人（HC）（136例）进行回顾性队列研究。结果SPTB组患者平均年龄（40.43±19.85岁）低于APTB组（50.01±21.49岁）(p <；0.05)。与HC组相比，两组肺结核患者白细胞计数均升高(p <；0.05)。APTB组CRP和CA-125高于SPTB和HC组(p <；0.05)。SPTB组CD4+ T细胞计数低于HC组(p <；0.05);虽然SPTB组CD4+ T细胞计数低于APTB组，但差异无统计学意义(p >；0.05)。三组患者CD8 + T细胞计数差异有统计学意义(p <；两组患者CD8 + T细胞计数均低于HC组(p <；0.05)， SPTB组与APTB组间差异无统计学意义(p >；0.05)。T-SPOT。SPTB组TB值低于APTB组(p <；0.05)。结论SPTB患者发病年龄较轻，且以男性为主。临床可通过监测WBC计数、CA-125、CRP、T淋巴细胞计数、T- spot等指标来判断SPTB是否会发展为APTB。TB值水平，以达到早期诊断和治疗的目的。

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Characteristics of subclinical pulmonary tuberculosis compared to active pulmonary tuberculosis: A retrospective cohort study

Background

Little is known about subclinical pulmonary tuberculosis (SPTB), and its diagnosis remains challenging. The aim is to analyze the results of laboratory of SPTB and improve clinical understanding and help early diagnosis.

Method

This retrospective cohort study was conducted in patients with pulmonary tuberculosis (TB) at a university hospital in China. 138 cases of SPTB were compared with active pulmonary tuberculosis (APTB) (140 cases) and healthy person (HC) (136 cases).

Result

The average age of the SPTB group (40.43 ± 19.85 years) was younger than that of the APTB group (50.01 ± 21.49 years) (p < 0.05). The WBC count was elevated in both pulmonary TB groups compared to the HC group(p < 0.05). CRP and CA-125 were higher in the APTB group than in SPTB and HC group (p < 0.05). The CD4+ T cells counts in SPTB group was lower than that in HC group (p < 0.05); although the CD4+ T cells counts in SPTB group was lower than that in APTB group, the difference was not statistically significant (p > 0.05). There were statistically significant differences in CD8 + T cells counts between the three groups (p < 0.05), and the CD8 + T cells counts in two pulmonary TB groups was lower than that in the HC group (p < 0.05), and there was no statistically significant difference between SPTB and APTB group (p > 0.05). The T-SPOT.TB value in SPTB were lower than those in the APTB group (p < 0.05).

Conclusion

Patients with SPTB tend to develop the condition at a younger age and are predominantly male. Clinically, we can judge whether SPTB will develop into APTB by monitoring WBC count, CA-125, CRP, T lymphocyte count and T-SPOT.TB value level, in order to achieve the purpose of early diagnosis and treatment.

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来源期刊

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Medicine-Pulmonary and Respiratory Medicine

CiteScore

4.00

自引率

5.00%

发文量

审稿时长

30 weeks

期刊介绍： Journal of Clinical Tuberculosis and Mycobacterial Diseases aims to provide a forum for clinically relevant articles on all aspects of tuberculosis and other mycobacterial infections, including (but not limited to) epidemiology, clinical investigation, transmission, diagnosis, treatment, drug-resistance and public policy, and encourages the submission of clinical studies, thematic reviews and case reports. Journal of Clinical Tuberculosis and Mycobacterial Diseases is an Open Access publication.