为室内尘埃中的化学物质制定公共卫生准则。第一个成就和接下来的步骤:铅的例子

P. Glorennec , A. Pelfrêne , J.-U. Mullot , B. Le Bot , C. Emond , C. Léger , D. Bourgeois
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引用次数: 0

摘要

关于化学品环境浓度的健康准则旨在防止有害化学品接触。然而,对于某些化学物质,尽管摄入室内沉降尘是一种有记录的接触途径,但却没有针对室内沉降尘的规定。本文的目的是提出一个基于健康的室内沉降尘指南(ISDG)的推导。制定该指南的目的是在考虑到其他接触途径的情况下,保护最脆弱人群的特定部分免受最敏感的影响。它是根据毒理学参考值、体重和吸入粉尘的质量计算出来的。最脆弱的人群是幼儿,相应的临界效应是智商点的损失,毒性参考值为0.5 µg.kgbw−1.d−1。假设受影响最严重的个体80% %的暴露来自粉尘摄入,则保护90%、95%或95% %幼儿的ISDG分别为43、33和20 µg。分别gdust−1。这些值始终低于会引发铅中毒筛查的浓度。主要的不确定因素在于对吸入尘埃量的估计。该可持续发展目标可有助于防止或减少铅接触的环境管理工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Setting public health guidelines for chemicals in indoor settled dust. First achievements and steps to come: The case of lead
Health based guidelines for environmental concentrations of chemicals are designed to prevent harmful chemical exposures. However, none exists for indoor settled dust, despite its ingestion being a documented pathway of exposure, for certain chemicals. The objective of this paper is to present the derivation of a health-based indoor settled dust guideline (ISDG) for lead. The guideline was developed to protect a specific fraction of the most vulnerable population against the most sensitive effect, taking into account other exposure pathways. It is calculated from a toxicological reference value, body weight, and the mass of ingested dust. The most vulnerable population is young children, and the corresponding critical effect is a loss of IQ points, with a toxicity reference value of 0.5 µg.kgbw−1.d−1. Assuming that 80 % of the exposure for the most affected individuals comes from dust ingestion, the ISDG for protecting 90, 95 or 95 % of young children are 43, 33 and 20 µg.gdust−1, respectively. These values are consistently lower than the concentrations that would trigger lead poisoning screening. The main uncertainties lie in the estimations of the amount of ingested dust. This ISDG could contribute to environmental management efforts to prevent or reduce lead exposures.
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