Theresa Lüth, Amke Caliebe, Carolin Gabbert, Sebastian Sendel, Björn-Hergen Laabs, Inke R. König, Christine Klein, Joanne Trinh
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引用次数: 0
摘要
关于生活方式暴露与运动严重程度之间关系的纵向调查尚缺乏。在这项纵向研究中，我们纳入了来自PPMI-Online和Fox Insight的特发性帕金森病（iPD） （N = 5139）和lrrk2相关PD （N = 81）患者。运动方面的随访时间长达5年。我们通过线性混合效应模型调查了环境暴露、生活方式因素和运动方面严重程度之间的关系。在LRRK2-PD中，饮用红茶与较轻的运动方面相关（β = - 0.51, p = 0.028）。在iPD患者中，随着时间的推移，农药暴露与更严重的运动方面相关（β = 0.23, p = 3.56 × 10−9）。最后，在PPMI-Online （β = 0.15, p = 3.84 × 10−8）和Fox Insight （β = 0.09, p = 0.031）中，含咖啡因苏打水与iPD患者更严重的运动方面相关。我们认为农药暴露和生活方式因素可能影响LRRK2-PD和iPD患者的运动严重程度，即使在发病后也会对患者产生影响。
Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson’s disease motor severity
Longitudinal investigations on the relationship between lifestyle exposures and motor severity are lacking. In this longitudinal study, we included patients with idiopathic Parkinson’s disease (iPD) (N = 5139) and LRRK2-related PD (N = 81) from PPMI-Online and Fox Insight. Motor aspects were followed for up to five years. We investigated the association between environmental exposure, lifestyle factors and motor aspect severity over time by applying linear mixed effects models. In LRRK2-PD, black tea consumption was associated with less severe motor aspects (β = −0.51, p = 0.028). In patients with iPD, pesticide exposure was associated with more severe motor aspects over time in PPMI-Online (β = 0.23, p = 3.56 × 10−9). Lastly, caffeinated soda was associated with more severe motor aspects in patients with iPD from PPMI-Online (β = 0.15, p = 3.84 × 10−8) and Fox Insight (β = 0.09, p = 0.031). We suggest that pesticide exposure and lifestyle factors may affect motor severity in patients with LRRK2-PD and iPD, demonstrating the impact on patients even after disease onset.
期刊介绍：
npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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