氮中心有机持久自由基催化氧化还原-中性C -C键形成反应

IF 16.9 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-06-13 DOI:10.1002/anie.202511233

Dr. Shrouq Mujahed, Dr. Jaysan Janabel, Dr. Kundan Shaw, Dr. Roberta Cagliani, Prof. Dr. Tynchtyk Amatov

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引用次数: 0

摘要

我们报道了氮中心的持久性自由基，Kuhn-verdazyls，是有效的，可调的基态氧化还原有机催化剂，用于单电子转移（SET）引发的自由基转化。在没有光或外界刺激的情况下，残基独特地模拟催化单电子穿梭，这是氧化还原催化的标志。它们能够实现氧化还原中性的C-C键形成反应，例如C-H芳基化和C-H三氟甲基化，通常由过渡金属、光氧化还原催化剂或机械氧化还原介质驱动，同时避免了在此类应用中限制有机超电子供体和氮氧化物的自抑制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Nitrogen-Centered Organic Persistent Radicals Catalyze Redox-Neutral C─C Bond Forming Reactions

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Nitrogen-Centered Organic Persistent Radicals Catalyze Redox-Neutral C─C Bond Forming Reactions

We report that nitrogen-centered persistent radicals, Kuhn verdazyls, are effective, tunable ground-state redox organocatalysts for single electron transfer (SET)-initiated radical transformations. Verdazyls uniquely emulate catalytic single-electron shuttling, a hallmark of redox catalysis, without light or external stimuli. They enable redox-neutral C─C bond-forming reactions, such as C─H arylation and C─H trifluoromethylation, typically driven by transition metals, photoredox catalysts, or mechanoredox mediators, while avoiding the self-inhibition that limits organic super electron donors and nitroxides in such applications.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.