Anna Lena Platzbecker, Janine Gronewold, Sara Schramm, Susanne Moebus, Andreas Stang, Börge Schmidt, Christian Weimar, Martha Jokisch
{"title":"已知2型糖尿病对5年后轻度认知障碍的性别和年龄特异性影响:基于人群的Heinz Nixdorf回忆研究结果","authors":"Anna Lena Platzbecker, Janine Gronewold, Sara Schramm, Susanne Moebus, Andreas Stang, Börge Schmidt, Christian Weimar, Martha Jokisch","doi":"10.1002/dad2.70130","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>As studies on the association between type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI), including amnestic (aMCI) and non-amnestic (naMCI) subtypes, vary by sex and age, we investigated the sex- and age-specific effects of T2DM on incident MCI after five years in a population-based sample.</p><p><strong>Methods: </strong>A total of 145 participants with T2DM and 1322 without T2DM were included. MCI was defined using established criteria excluding subjective cognitive decline. Adjusted relative risks (aRRs) were calculated considering age, education, body mass index, smoking, and alcohol intake, and stratified by sex and age (middle-aged: 50-65 years; old-aged: 66-80 years).</p><p><strong>Results: </strong>MCI occurred in 39.3% (<i>n</i> = 57) of participants with T2DM versus 27.5% (<i>n</i> = 363) without (aRR: 1.29, 95% confidence interval [CI]: 0.97-1.73). Middle-aged men showed an association with naMCI (aRR: 2.35, 95% CI: 1.26-4.39) and middle-aged women with aMCI (aRR: 2.05, 95% CI: 0.58-7.21).</p><p><strong>Discussion: </strong>T2DM increases MCI risk, particularly in middle-aged individuals with poorly controlled T2DM, emphasizing the need for prevention strategies.</p><p><strong>Highlights: </strong>Longitudinal results from the population-based Heinz Nixdorf Recall study in Germany.Incident mild cognitie impairment (MCI) was more common in type 2 diabetes mellitus (T2DM; 39% vs 28%).T2DM affects incident MCI and subtypes in middle-aged, not old-aged; stronger in men with poorly controlled T2DM.Importance of enhancing age- and sex-specific prevention at the population level.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 2","pages":"e70130"},"PeriodicalIF":4.4000,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152370/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sex- and age-specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later: Results from the population-based Heinz Nixdorf Recall study.\",\"authors\":\"Anna Lena Platzbecker, Janine Gronewold, Sara Schramm, Susanne Moebus, Andreas Stang, Börge Schmidt, Christian Weimar, Martha Jokisch\",\"doi\":\"10.1002/dad2.70130\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>As studies on the association between type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI), including amnestic (aMCI) and non-amnestic (naMCI) subtypes, vary by sex and age, we investigated the sex- and age-specific effects of T2DM on incident MCI after five years in a population-based sample.</p><p><strong>Methods: </strong>A total of 145 participants with T2DM and 1322 without T2DM were included. MCI was defined using established criteria excluding subjective cognitive decline. Adjusted relative risks (aRRs) were calculated considering age, education, body mass index, smoking, and alcohol intake, and stratified by sex and age (middle-aged: 50-65 years; old-aged: 66-80 years).</p><p><strong>Results: </strong>MCI occurred in 39.3% (<i>n</i> = 57) of participants with T2DM versus 27.5% (<i>n</i> = 363) without (aRR: 1.29, 95% confidence interval [CI]: 0.97-1.73). Middle-aged men showed an association with naMCI (aRR: 2.35, 95% CI: 1.26-4.39) and middle-aged women with aMCI (aRR: 2.05, 95% CI: 0.58-7.21).</p><p><strong>Discussion: </strong>T2DM increases MCI risk, particularly in middle-aged individuals with poorly controlled T2DM, emphasizing the need for prevention strategies.</p><p><strong>Highlights: </strong>Longitudinal results from the population-based Heinz Nixdorf Recall study in Germany.Incident mild cognitie impairment (MCI) was more common in type 2 diabetes mellitus (T2DM; 39% vs 28%).T2DM affects incident MCI and subtypes in middle-aged, not old-aged; stronger in men with poorly controlled T2DM.Importance of enhancing age- and sex-specific prevention at the population level.</p>\",\"PeriodicalId\":53226,\"journal\":{\"name\":\"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring\",\"volume\":\"17 2\",\"pages\":\"e70130\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2025-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152370/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/dad2.70130\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/dad2.70130","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Sex- and age-specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later: Results from the population-based Heinz Nixdorf Recall study.
Introduction: As studies on the association between type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI), including amnestic (aMCI) and non-amnestic (naMCI) subtypes, vary by sex and age, we investigated the sex- and age-specific effects of T2DM on incident MCI after five years in a population-based sample.
Methods: A total of 145 participants with T2DM and 1322 without T2DM were included. MCI was defined using established criteria excluding subjective cognitive decline. Adjusted relative risks (aRRs) were calculated considering age, education, body mass index, smoking, and alcohol intake, and stratified by sex and age (middle-aged: 50-65 years; old-aged: 66-80 years).
Results: MCI occurred in 39.3% (n = 57) of participants with T2DM versus 27.5% (n = 363) without (aRR: 1.29, 95% confidence interval [CI]: 0.97-1.73). Middle-aged men showed an association with naMCI (aRR: 2.35, 95% CI: 1.26-4.39) and middle-aged women with aMCI (aRR: 2.05, 95% CI: 0.58-7.21).
Discussion: T2DM increases MCI risk, particularly in middle-aged individuals with poorly controlled T2DM, emphasizing the need for prevention strategies.
Highlights: Longitudinal results from the population-based Heinz Nixdorf Recall study in Germany.Incident mild cognitie impairment (MCI) was more common in type 2 diabetes mellitus (T2DM; 39% vs 28%).T2DM affects incident MCI and subtypes in middle-aged, not old-aged; stronger in men with poorly controlled T2DM.Importance of enhancing age- and sex-specific prevention at the population level.
期刊介绍:
Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.