观察和等待的持续发展。

IF 1.1 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY

Clinics in Colon and Rectal Surgery Pub Date : 2024-11-04 eCollection Date: 2025-07-01 DOI:10.1055/s-0044-1791722

Mikhael Belkovsky, Ali Alipouriani, Arielle E Kanters, Joshua Sommovilla, Emre Gorgun, David Liska, Scott R Steele

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引用次数: 0

摘要

直肠癌的非手术治疗，被称为观察和等待（W&W），近年来得到越来越多的接受。该方法基于使用完全临床反应（cCR）作为新辅助放化疗（nCRT）后完全病理反应（pCR）的标志物。nCRT方案的进步导致更高的肿瘤消退率，使W&W成为特定患者的可行选择。本研究介绍了W&W策略的历史演变和疗效，并根据最近的临床发现提出了现代建议。主要发现包括达到cCR的患者的5年无病生存率为85%至92%，突出了在不影响生存结果的情况下改善生活质量和降低发病率的潜力。

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The Ongoing Development of Watch and Wait.

The nonoperative management of rectal cancer, known as watch and wait (W&W), has gained increasing acceptance in recent years. This approach is based on using complete clinical response (cCR) as a marker for complete pathological response (pCR) following neoadjuvant chemoradiation (nCRT). Advances in nCRT regimens have resulted in higher tumor regression rates, making W&W a viable option for selected patients. This study presents the historical evolution and efficacy of the W&W strategy and offers modern recommendations based on recent clinical findings. Key findings include an 85 to 92% 5-year disease-free survival rate in patients achieving cCR, highlighting the potential for improved quality of life and reduced morbidity without compromising survival outcomes.

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来源期刊

Clinics in Colon and Rectal Surgery GASTROENTEROLOGY & HEPATOLOGYSURGERY-SURGERY

CiteScore

2.60

自引率

7.10%

发文量

期刊介绍： Clinics in Colon and Rectal Surgery is a review journal that publishes topic-specific issues on diseases of the small bowel, colon, rectum, and anus. Designed for clinicians, researchers, and educators involved with diseases of the intestinal tract, the journal covers a broad spectrum of basic information, controversial clinical issues, and established and innovative diagnostic techniques. Issue topics comprehensively cover the entire specialty over a 3-4 year period, allowing the articles to serve as study material for educational programs and certifying examinations. The inclusion of research and clinical material also allows physicians to remain knowledgeable of current advances in the specialty.