循环短链脂肪酸在阿尔茨海默病中的作用：一项横断面观察研究。

IF 3.1 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-07-01 Epub Date: 2025-06-12 DOI:10.1177/13872877251337773

Moira Marizzoni, Luigi Coppola, Cristina Festari, Delia Luongo, Dominic Salamone, Daniele Naviglio, Andrea Soricelli, Peppino Mirabelli, Marco Salvatore, Annamaria Cattaneo, Giovanni B Frisoni

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引用次数: 0

摘要

短链脂肪酸（SCFAs）主要由肠道微生物产生，可能在阿尔茨海默病（AD）的病理生理中发挥作用。我们检查了28例AD认知障碍患者（CI-AD）、29例非AD认知障碍患者（CI-NAD）和10例认知未受损患者（CU）的SCFAs谱。与CU和CI-NAD相比，CI-AD的乙酸盐和戊酸盐含量较高，丁酸盐含量较低(p

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Circulating short chain fatty acids in Alzheimer's disease: A cross-sectional observational study.

Short chain fatty acids (SCFAs), produced mainly by gut microbes, might play a role in the pathophysiology of Alzheimer's disease (AD). We examined the SCFAs profile in 28 individuals with cognitive impairment due to AD (CI-AD), 29 with cognitive impairment not due to AD (CI-NAD), and 10 cognitively unimpaired (CU). CI-AD showed higher levels of acetate and valerate and lower levels of butyrate than CU and CI-NAD (p < 0.018). Acetate separated CI-AD from CI-NAD with AUC = 0.95 while the best neurodegeneration-related biomarker was GFAP with AUC = 0.79. SCFAs use for diagnosis and as treatment target in AD deserve further studies.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.