Timothy English, Joshua Barton, Nicole Vargas, Michael Barnett, Ollie Jay
{"title":"分离多发性硬化症中热敏性的知觉和生理因素：来自一个新的实验模型的见解。","authors":"Timothy English, Joshua Barton, Nicole Vargas, Michael Barnett, Ollie Jay","doi":"10.1007/s00421-025-05838-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To determine if reductions in whole-body thermal sensation (WBTS) with localised skin cooling mitigate heat-induced visual performance decrements in people with multiple sclerosis (MS), optic neuritis, and heat-sensitive visual symptoms, independent of core temperature increases.</p><p><strong>Methods: </strong>Thirteen participants (7 relapsing-remitting MS (MS) patients with unilateral (left) optic neuritis and heat-sensitive visual symptoms; 6 controls) underwent visual performance testing on each eye at baseline and during passive heating (0.6℃ rise in gastrointestinal temperature (ΔT<sub>GI</sub>) via a hot water-perfused suit) under two counterbalanced crossover ordered conditions: 1) cold packs (0℃-CLD) or 2) hot packs (50℃-HOT) applied to the lower back. WBTS, visual symptoms, multifocal visual evoked potentials (mf-VEPs) amplitude/latency, and contrast sensitivity were assessed.</p><p><strong>Results: </strong>ΔT<sub>GI</sub> was consistent across trials (p = 0.213; η<sub>p</sub><sup>2</sup> = 0.21). WBTS was only marginally lower (p = 0.017; η<sub>p</sub><sup>2</sup> = 0.42) in CLD than HOT for MS (CLD: 5.8 ± 0.9 a.u.; HOT: 6.4 ± 0.7 a.u.) and controls (CLD: 5.0 ± 0.9 a.u.; HOT: 5.9 ± 0.7 a.u.). Passive heating worsened (p = 0.027; η<sub>p</sub><sup>2</sup> = 0.59) visual symptoms in the affected eye similarly (p = 0.356; η<sub>p</sub><sup>2</sup> = 0.14) for HOT and CLD conditions. Heating reduced mf-VEPs amplitude in the left (affected) eye (p = 0.007; η<sub>p</sub><sup>2</sup> = 0.50) similarly (p = 0.332; η<sub>p</sub><sup>2</sup> = 0.09) across groups and conditions. For the unaffected (right) eye, reductions in mf-VEPs amplitude were greater in MS than controls (p = 0.031; η<sub>p</sub><sup>2</sup> = 0.36), with no difference between conditions (p = 0.339; η<sub>p</sub><sup>2</sup> = 0.08). mf-VEPs latency and contrast sensitivity were unaffected by heating.</p><p><strong>Conclusion: </strong>Localised skin cooling during passive heating to a moderate core temperature produces only a modest reduction in WBTS and does not mitigate heat-induced visual performance decrements. The limited perceptual difference achieved suggests the localised skin cooling was insufficient to meaningfully isolate the effects of skin temperature from core temperature.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Toward isolating perceptual and physiological contributors to heat sensitivity in multiple sclerosis: insights from a new experimental model.\",\"authors\":\"Timothy English, Joshua Barton, Nicole Vargas, Michael Barnett, Ollie Jay\",\"doi\":\"10.1007/s00421-025-05838-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To determine if reductions in whole-body thermal sensation (WBTS) with localised skin cooling mitigate heat-induced visual performance decrements in people with multiple sclerosis (MS), optic neuritis, and heat-sensitive visual symptoms, independent of core temperature increases.</p><p><strong>Methods: </strong>Thirteen participants (7 relapsing-remitting MS (MS) patients with unilateral (left) optic neuritis and heat-sensitive visual symptoms; 6 controls) underwent visual performance testing on each eye at baseline and during passive heating (0.6℃ rise in gastrointestinal temperature (ΔT<sub>GI</sub>) via a hot water-perfused suit) under two counterbalanced crossover ordered conditions: 1) cold packs (0℃-CLD) or 2) hot packs (50℃-HOT) applied to the lower back. WBTS, visual symptoms, multifocal visual evoked potentials (mf-VEPs) amplitude/latency, and contrast sensitivity were assessed.</p><p><strong>Results: </strong>ΔT<sub>GI</sub> was consistent across trials (p = 0.213; η<sub>p</sub><sup>2</sup> = 0.21). WBTS was only marginally lower (p = 0.017; η<sub>p</sub><sup>2</sup> = 0.42) in CLD than HOT for MS (CLD: 5.8 ± 0.9 a.u.; HOT: 6.4 ± 0.7 a.u.) and controls (CLD: 5.0 ± 0.9 a.u.; HOT: 5.9 ± 0.7 a.u.). Passive heating worsened (p = 0.027; η<sub>p</sub><sup>2</sup> = 0.59) visual symptoms in the affected eye similarly (p = 0.356; η<sub>p</sub><sup>2</sup> = 0.14) for HOT and CLD conditions. Heating reduced mf-VEPs amplitude in the left (affected) eye (p = 0.007; η<sub>p</sub><sup>2</sup> = 0.50) similarly (p = 0.332; η<sub>p</sub><sup>2</sup> = 0.09) across groups and conditions. For the unaffected (right) eye, reductions in mf-VEPs amplitude were greater in MS than controls (p = 0.031; η<sub>p</sub><sup>2</sup> = 0.36), with no difference between conditions (p = 0.339; η<sub>p</sub><sup>2</sup> = 0.08). mf-VEPs latency and contrast sensitivity were unaffected by heating.</p><p><strong>Conclusion: </strong>Localised skin cooling during passive heating to a moderate core temperature produces only a modest reduction in WBTS and does not mitigate heat-induced visual performance decrements. The limited perceptual difference achieved suggests the localised skin cooling was insufficient to meaningfully isolate the effects of skin temperature from core temperature.</p>\",\"PeriodicalId\":12005,\"journal\":{\"name\":\"European Journal of Applied Physiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Applied Physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00421-025-05838-7\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Applied Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00421-025-05838-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Toward isolating perceptual and physiological contributors to heat sensitivity in multiple sclerosis: insights from a new experimental model.
Purpose: To determine if reductions in whole-body thermal sensation (WBTS) with localised skin cooling mitigate heat-induced visual performance decrements in people with multiple sclerosis (MS), optic neuritis, and heat-sensitive visual symptoms, independent of core temperature increases.
Methods: Thirteen participants (7 relapsing-remitting MS (MS) patients with unilateral (left) optic neuritis and heat-sensitive visual symptoms; 6 controls) underwent visual performance testing on each eye at baseline and during passive heating (0.6℃ rise in gastrointestinal temperature (ΔTGI) via a hot water-perfused suit) under two counterbalanced crossover ordered conditions: 1) cold packs (0℃-CLD) or 2) hot packs (50℃-HOT) applied to the lower back. WBTS, visual symptoms, multifocal visual evoked potentials (mf-VEPs) amplitude/latency, and contrast sensitivity were assessed.
Results: ΔTGI was consistent across trials (p = 0.213; ηp2 = 0.21). WBTS was only marginally lower (p = 0.017; ηp2 = 0.42) in CLD than HOT for MS (CLD: 5.8 ± 0.9 a.u.; HOT: 6.4 ± 0.7 a.u.) and controls (CLD: 5.0 ± 0.9 a.u.; HOT: 5.9 ± 0.7 a.u.). Passive heating worsened (p = 0.027; ηp2 = 0.59) visual symptoms in the affected eye similarly (p = 0.356; ηp2 = 0.14) for HOT and CLD conditions. Heating reduced mf-VEPs amplitude in the left (affected) eye (p = 0.007; ηp2 = 0.50) similarly (p = 0.332; ηp2 = 0.09) across groups and conditions. For the unaffected (right) eye, reductions in mf-VEPs amplitude were greater in MS than controls (p = 0.031; ηp2 = 0.36), with no difference between conditions (p = 0.339; ηp2 = 0.08). mf-VEPs latency and contrast sensitivity were unaffected by heating.
Conclusion: Localised skin cooling during passive heating to a moderate core temperature produces only a modest reduction in WBTS and does not mitigate heat-induced visual performance decrements. The limited perceptual difference achieved suggests the localised skin cooling was insufficient to meaningfully isolate the effects of skin temperature from core temperature.
期刊介绍：
The European Journal of Applied Physiology (EJAP) aims to promote mechanistic advances in human integrative and translational physiology. Physiology is viewed broadly, having overlapping context with related disciplines such as biomechanics, biochemistry, endocrinology, ergonomics, immunology, motor control, and nutrition. EJAP welcomes studies dealing with physical exercise, training and performance. Studies addressing physiological mechanisms are preferred over descriptive studies. Papers dealing with animal models or pathophysiological conditions are not excluded from consideration, but must be clearly relevant to human physiology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
